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Enbo Te Ma

from Moraga, CA
Age ~65
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Also known as:
Enbo B Ma, Ma Te Enbo, Embo Ma, James Mclmayhlin
Phone and address:
1557 Del Monte Ct, Moraga, CA 94556
(925) 377-0509
Related to:
Pinfang L Ma, 81
Connected to:
Ah N Ma, 70Aileen B Ma, 51Akana K Ma, 68Alex B Ma, 49Alexandra Ma, 33Allan Ma, 38Anni Ma, 39Annie Ma, 49Athena Ma, 30Ayan S Ma, 38

Enbo Ma Phones & Addresses

  • 1557 Del Monte Ct, Moraga, CA 94556 (925) 377-0509
  • 1517 Del Monte Ct, Moraga, CA 94556
  • 2 Barberry Ln, Woodbridge, CT 06525 (203) 389-4975
  • Richmond, CA
  • Berkeley, CA
  • Fort Lauderdale, FL

Publications

Us Patents

Modified Dicer Polypeptide And Methods Of Use Thereof

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US Patent:
20110117610, May 19, 2011
Filed:
Mar 18, 2009
Appl. No.:
12/922428
Inventors:
Jennifer Doudna - Berkeley CA, US
Enbo Ma - Berkeley CA, US
Ian J. Macrae - San Diego CA, US
International Classification:
C12P 19/34
C12N 9/22
C12N 1/00
C12N 15/63
C07H 21/04
US Classification:
435 913, 435199, 435243, 4353201, 536 232
Abstract:
A modified Dicer polypeptide is provided, which modified Dicer polypeptide exhibits enhanced catalytic activity. Also provided is a method for producing small regulatory RNAs from a dsRNA, involving contacting a dsRNA with a subject modified Dicer. Small regulatory RNAs produced by a subject method find use in a variety of applications, including research and therapeutic applications.

Method Of Producing Dicer

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US Patent:
20130196383, Aug 1, 2013
Filed:
Aug 2, 2012
Appl. No.:
13/565453
Inventors:
Jennifer A. Doudna - Berkeley CA, US
Enbo Ma - Moraga CA, US
International Classification:
C12N 9/16
US Classification:
435 913, 435196, 4353201, 4352523, 43525233, 43525231, 43525234
Abstract:
The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure further provides kits for producing a Dicer polypeptide in a prokaryotic host cell.

Variant Type V Crispr/Cas Effector Polypeptides And Methods Of Use Thereof

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US Patent:
20220315914, Oct 6, 2022
Filed:
Jul 6, 2020
Appl. No.:
17/619815
Inventors:
- Oakland CA, US
Enbo Ma - Moraga CA, US
Junjie Liu - Berkeley CA, US
International Classification:
C12N 15/10
C12N 15/11
C12N 15/82
C12N 15/85
Abstract:
The present disclosure provides variant type V CRISPR/Cas effector polypeptides, nucleic acids encoding the variant polypeptides, and systems comprising the variant polypeptides or nucleic acids encoding same. The present disclosure provides methods for modifying a target nucleic acid, using a variant polypeptide of the present disclosure.

Type V Crispr/Cas Effector Proteins For Cleaving Ssdnas And Detecting Target Dnas

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US Patent:
20210388437, Dec 16, 2021
Filed:
Jul 29, 2021
Appl. No.:
17/388321
Inventors:
- Oakland CA, US
Janice S. Chen - Berkeley CA, US
Lucas Benjamin Harrington - Berkeley CA, US
Enbo Ma - Moraga CA, US
International Classification:
C12Q 1/6876
C12N 15/11
C12N 9/22
C12Q 1/6823
Abstract:
Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell.

Type V Crispr/Cas Effector Proteins For Cleaving Ssdnas And Detecting Target Dnas

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US Patent:
20200399697, Dec 24, 2020
Filed:
Jul 13, 2020
Appl. No.:
16/927351
Inventors:
- Oakland CA, US
Janice S. Chen - Berkeley CA, US
Lucas Benjamin Harrington - Berkeley CA, US
Enbo Ma - Moraga CA, US
International Classification:
C12Q 1/6876
C12Q 1/6823
C12N 9/22
C12N 15/11
Abstract:
Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell.

Type V Crispr/Cas Effector Proteins For Cleaving Ssdnas And Detecting Target Dnas

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US Patent:
20200299768, Sep 24, 2020
Filed:
Jun 9, 2020
Appl. No.:
16/896731
Inventors:
- Oakland CA, US
Janice S. Chen - Berkeley CA, US
Lucas Benjamin Harrington - Berkeley CA, US
Enbo Ma - Moraga CA, US
International Classification:
C12Q 1/6876
C12N 15/11
C12N 9/22
C12Q 1/6823
Abstract:
Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell.

Type V Crispr/Cas Effector Proteins For Cleaving Ssdnas And Detecting Target Dnas

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US Patent:
20190241954, Aug 8, 2019
Filed:
Jan 30, 2019
Appl. No.:
16/262257
Inventors:
- Oakland CA, US
Janice S. Chen - Berkeley CA, US
Lucas Benjamin Harrington - Berkeley CA, US
Enbo Ma - Moraga CA, US
International Classification:
C12Q 1/6876
C12N 9/22
C12N 15/11
Abstract:
Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell.

Method Of Producing Dicer

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US Patent:
20150361406, Dec 17, 2015
Filed:
Aug 25, 2014
Appl. No.:
14/468109
Inventors:
- Oakland CA, US
Enbo Ma - Moraga CA, US
International Classification:
C12N 9/22
C12N 15/113
Abstract:
The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure further provides kits for producing a Dicer polypeptide in a prokaryotic host cell.
Control profile
Enbo Te Ma from Moraga, CA, age ~65 Get Report