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Emily Agnes Stonehouse

from Lebanon, NH
Age ~45
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Also known as:
Emily A Stonehouse
Phone and address:
70 Sunset Rock Rd, Lebanon, NH 03766
Related to:
Michele Brozanski, 57Mark R Dunn, 64
Connected to:
Brian J Stonehocker, 51Curtis L Stonehocker, 70Dustin Stonehocker, 44Hayley L Stonehouse, 27James Stonehocker, 65Joseph H Stonehocker, 40Lisa M Stonehouse, 49Loren W Stonehocker, 52Margaret A Stonehouse, 78Matthew J Stonehouse, 42

Emily Stonehouse Phones & Addresses

  • 70 Sunset Rock Rd, Lebanon, NH 03766
  • Etna, NH
  • North Hartland, VT
  • Norwich, VT
  • East Thetford, VT
  • Rochester Hills, MI
  • Hanover, NH
  • Middlebury, VT
  • 35 Parkhurst St APT 3, Lebanon, NH 03766

Work

Position: Administration/Managerial

Resumes

Resumes

Emily Stonehouse Photo 1

R And D Manager

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Location:
Lebanon, NH
Industry:
Biotechnology
Work:
Mascoma Llc
R and D Manager
Mascoma Llc
Research Scientist
Education:
Dartmouth College
Doctorates, Doctor of Philosophy, Microbiology Middlebury College
Bachelors, Bachelor of Arts, Molecular Biology, Biochemistry
Skills:
Molecular Biology
Microbiology
Biotechnology
Biochemistry
Fermentation
Protein Purification
Yeast
Life Sciences
Metabolic Engineering
Pcr
Western Blotting
Protein Expression
Project Leadership
Interests:
Education
Environment
Science and Technology
Arts and Culture
Health
Emily Stonehouse Photo 2

Emily Stonehouse

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Publications

Us Patents

Yeast Expressing Saccharolytic Enzymes For Consolidated Bioprocessing Using Starch And Cellulose

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US Patent:
20130323822, Dec 5, 2013
Filed:
Jun 3, 2011
Appl. No.:
13/701652
Inventors:
Elena Brevnova - Lebanon NH, US
John E. McBride - Lyme NH, US
Erin Wiswall - Danbury NH, US
Kevin S. Wenger - Hanover NH, US
Nicky Caiazza - Lebanon NH, US
Heidi Hau - Lebanon NH, US
Aaron Argyros - White River Junction VT, US
Frank Agbogbo - Lebanon NH, US
Charles F. Rice - Hopkinton NH, US
Trisha Barrett - Bradford VT, US
John S. Bardsley - Newport NH, US
Abigail S. Foster - South Strafford VT, US
Anne K. Warner - Lebanon NH, US
Mark Mellon - Grantham NH, US
Ryan Skinner - White River Junction VT, US
Indraneel Shikhare - Lebanon NH, US
Riaan Den Haan - Vierlanden, ZA
Chhayal V. Gandhi - Lebanon NH, US
Alan Belcher - Nashua NH, US
Vineet B. Rajgarhia - Courbevoie, FR
Allan C. Froehlich - Lebanon NH, US
Kristen M. Deleault - Canaan NH, US
Emily Stonehouse - Lebanon NH, US
Shital A. Tripathi - Berkley CA, US
Jennifer Gosselin - Lebanon NH, US
Yin-Ying Chiu - West Lebanon NH, US
Haowen Xu - Lebanon NH, US
Assignee:
Mascoma Corporation - Lebanon NH
International Classification:
C12N 15/81
US Classification:
43525421
Abstract:
The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

Yeast Expressing Cellulases For Simultaneous Saccharification And Fermentation Using Cellulose

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US Patent:
20120129229, May 24, 2012
Filed:
Nov 23, 2009
Appl. No.:
13/130549
Inventors:
John McBride - Lyme NH, US
Elena Brevnova - Lebanon NH, US
Mark Mellon - Grantham NH, US
Allan Froehlich - Lebanon NH, US
Kristen Deleault - Canaan NH, US
Vineet Rajgarhia - Dublin CA, US
Riaan Den Haan - Durbanville, ZA
Merja Penttila - Helsinki, FI
Marja Ilmen - Helsinki, FI
Matti Siika-Aho - Helsinki, FI
Jaana Uusitalo - Espoo, FI
Emily A. Stonehouse - Lebanon NH, US
Alan Gilbert - Cambridge MA, US
Haowen Xu - Lebanon NH, US
Deidre Willes - Lebanon NH, US
John Bardsley - Newport NH, US
Anu Koivula - Helsinki, FI
Sanni Voutilainen - Siuntio, FI
International Classification:
C12N 1/19
C12P 19/02
US Classification:
435105, 4352542
Abstract:
Host cells, comprising expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes

Yeast Expressing Saccharolytic Enzymes For Consolidated Bioprocessing Using Starch And Cellulose

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US Patent:
20230028975, Jan 26, 2023
Filed:
Oct 13, 2021
Appl. No.:
17/500501
Inventors:
- Budapest, HU
- Stellenbosch, ZA
Erin Wiswall - Danbury NH, US
Kevin S. Wenger - Hanover NH, US
Nicky Caiazza - Rancho Santa Fe CA, US
Heidi Hau - Lebanon NH, US
Aaron Argyros - White River Junction VT, US
Frank Agbogbo - Lebanon NH, US
Charles F. Rice - Hopkinton NH, US
Trisha Barrett - Bradford VT, US
John S. Bardsley - Newport NH, US
Abigail Foster - South Strafford VT, US
Anne K. Warner - Lebanon NH, US
Mark Mellon - Grantham NH, US
Ryan Skinner - White River Junction VT, US
Indraneel Shikhare - Lebanon NH, US
Riaan Den Haan - Vierlanden, ZA
Chhayal V. Gandhi - Lebanon NH, US
Alan Belcher - Nashua NH, US
Vineet B. Rajgarhia - Courbevoie, FR
Allan C. Froehlich - Lebanon NH, US
Kristen M. Deleault - Canaan NH, US
Emily Stonehouse - Lebanon NH, US
Shital A. Tripathi - Berkeley CA, US
Jennifer Gosselin - Lebanon NH, US
Yin-Ying Chiu - West Lebanon NH, US
Haowen Xu - Lebanon NH, US
International Classification:
C12N 15/81
C12N 9/42
C12N 9/24
C12N 15/52
C12P 7/06
Abstract:
The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

Yeast Expressing Cellulases For Simultaneous Saccharification And Fermentation Using Cellulose

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US Patent:
20210388398, Dec 16, 2021
Filed:
Dec 22, 2020
Appl. No.:
17/131293
Inventors:
- Budapest, HU
- Stellenbosch, ZA
Mark Mellon - Grantham NH, US
Allan Froehlich - Lebanon NH, US
Kristen Deleault - Canaan NH, US
Vineet Rajgarhia - Dublin CA, US
Riaan Den Haan - Vierlanden, ZA
Merja Penttila - Helsinki, FI
Marja Ilmen - Helsinki, FI
Matti Siika-Aho - Helsinki, FI
Jaana Uusitalo - Espoo, FI
Emily A. Stonehouse - Lebanon NH, US
Alan Gilbert - Cambridge MA, US
Haowen Xu - Lebanon NH, US
Deidre Willies - Lebanon HH, US
John Bardsley - Newport NH, US
Anu Koivula - Helsinki, FI
Sanni Voutilainen - Siuntio, FI
International Classification:
C12P 7/10
C12N 15/80
C12P 7/14
C12P 39/00
C12N 9/42
Abstract:
The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

Yeast Expressing Saccharolytic Enzymes For Consolidated Bioprocessing Using Starch And Cellulose

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US Patent:
20200095592, Mar 26, 2020
Filed:
May 30, 2019
Appl. No.:
16/426563
Inventors:
- Budapest, HU
Erin Wiswall - Danbury NH, US
Kevin S. Wenger - Hanover NH, US
Nicky Caiazza - Rancho Santa Fe CA, US
Heidi Hau - Lebanon NH, US
Aaron Argyros - White River Junction VT, US
Frank Agbogbo - Lebanon NH, US
Charles F. Rice - Hopkinton NH, US
Trisha Barrett - Bradford VT, US
John S. Bardsley - Newport NH, US
Abigail Foster - South Strafford VT, US
Anne K. Warner - Lebanon NH, US
Mark Mellon - Grantham NH, US
Ryan Skinner - White River Junction VT, US
Indraneel Shikhare - Lebanon NH, US
Riaan Den Haan - Vierlanden, ZA
Chhayal V. Gandhi - Lebanon NH, US
Alan Belcher - Nashua NH, US
Vineet B. Rajgarhia - Courbevoie, FR
Allan C. Froehlich - Lebanon NH, US
Kristen M. Deleault - Canaan NH, US
Emily Stonehouse - Lebanon NH, US
Shital A. Tripathi - Berkeley CA, US
Jennifer Gosselin - Lebanon NH, US
Yin-Ying Chiu - West Lebanon NH, US
Haowen Xu - Lebanon NH, US
International Classification:
C12N 15/81
C12N 9/42
C12N 9/24
C12P 7/06
C12N 15/52
Abstract:
The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

Yeast Expressing Cellulases For Simultaneous Saccharification And Fermentation Using Cellulose

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US Patent:
20180258449, Sep 13, 2018
Filed:
May 21, 2018
Appl. No.:
15/985042
Inventors:
- Budapest, HU
- Stellenbosch, ZA
Mark Mellon - Grantham NH, US
Allan Froehlich - Lebanon NH, US
Kristen Deleault - Canaan NH, US
Vineet Rajgarhia - Dublin CA, US
Riaan Den Haan - Durbanville, ZA
Merja Penttila - Helsinki, FI
Marja Ilmen - Helsinki, FI
Matti Siika-Aho - Helsinki, FI
Jaana Uusitalo - Espoo, FI
Emily A. Stonehouse - Lebanon NH, US
Alan Gilbert - Cambridge MA, US
Haowen Xu - Lebanon NH, US
Deidre Willies - Lebanon NH, US
John Bardsley - Newport NH, US
Anu Koivula - Helsinki, FI
Sanni Voutilainen - Siuntio, FI
International Classification:
C12P 7/10
C12N 15/80
C12P 7/14
C12P 39/00
C12N 9/42
Abstract:
The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

Yeast Expressing Saccharolytic Enzymes For Consolidated Bioprocessing Using Starch And Cellulose

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US Patent:
20170240906, Aug 24, 2017
Filed:
May 2, 2017
Appl. No.:
15/584473
Inventors:
- Budapest, HU
John E. McBride - Lyme NH, US
Erin Wiswall - Danbury NH, US
Kevin S. Wenger - Hanover NH, US
Nicky Caiazza - Rancho Santa Fe CA, US
Heidi Hau - Lebanon NH, US
Aaron Argyros - White River Junction VT, US
Frank Agbogbo - Lebanon NH, US
Charles F. Rice - Hopkinton NH, US
Trisha Barrett - Bradford VT, US
John S. Bardsley - Newport NH, US
Abigail Foster - South Strafford VT, US
Anne K. Warner - Lebanon NH, US
Mark Mellon - Grantham NH, US
Ryan Skinner - White River Junction VT, US
Indraneel Shikhare - Lebanon NH, US
Riaan Den Haan - Vierlanden, ZA
Chhayal V. Gandhi - Lebanon NH, US
Alan Belcher - Nashua NH, US
Vineet B. Rajgarhia - Courbevoie, FR
Allan C. Froehlich - Lebanon NH, US
Kristen M. Deleault - Canaan NH, US
Emily Stonehouse - Lebanon NH, US
Shital A. Tripathi - Berkley CA, US
Jennifer Gosselin - Lebanon NH, US
Yin-Ying Chiu - West Lebanon NH, US
Haowen Xu - Lebanon NH, US
International Classification:
C12N 15/52
C12N 9/42
Abstract:
The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

Methods For The Improvement Of Product Yield And Production In A Microorganism Through Glycerol Recycling

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US Patent:
20160194669, Jul 7, 2016
Filed:
Aug 15, 2014
Appl. No.:
14/911102
Inventors:
- Budapest, HU
William R. Kenealy - West Lebanon NH, US
Emily Stonehouse - Lebanon NH, US
International Classification:
C12P 7/06
C12P 7/04
C12N 15/81
Abstract:
The present invention provides for novel metabolic pathways to reduce or modulate glycerol production and increase product formation. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous proteins that function to import glycerol and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source, such as lignocellulose, to a product, such as ethanol, wherein the one or more native and/or heterologous proteins or enzymes is activated, upregulated, or downregulated. The invention also provides for a recombinant microorganism comprising one or more native or heterologous proteins that function to regulate glycerol synthesis and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source to ethanol, wherein said one or more native and/or heterologous proteins or enzymes is activated, upregulated or downregulated. Also provided are methods for increasing cellular glycerol uptake and increasing recombinant production of fuels and other chemicals using the recombinant microorganisms of the invention.
Control profile
Emily Agnes Stonehouse from Lebanon, NH, age ~45 Get Report