US Patent:
20060263389, Nov 23, 2006
Inventors:
Sue Stacy - San Antonio TX, US
Ellen Kraig - San Antonio TX, US
Peter Dube - San Antonio TX, US
International Classification:
A61K 39/02
A61K 39/08
A61K 48/00
US Classification:
424234100, 424239100, 514044000
Abstract:
The present invention provides a composition comprising a chimeric polypeptide comprising a recall antigen that reactivates memory T cells in a subject and a new antigen that activates naïve B cells in a subject and a composition comprising a nucleic acid encoding a chimeric polypeptide comprising a recall antigen that reactivates memory T cells in a subject and a new antigen that activates naïve B cells in a subject. Further provided are methods of modulating an immune response, as well as treating and/or preventing disease in subjects in whom the ability to mount an immune response to a new antigen is impaired, by administering the compositions of this invention.
