Egidijus E Uzgiris

6419635, Jul 16, 2002

Aug 11, 2000

09/635463

Kristina Helena Valborg Hedengren - Schenectady NY
William Paul Kornrumpf - Schenectady NY
Mark Lloyd Miller - Schenectady NY
Egidijus Edward Uzgiris - Schenectady NY

General Electric Compsany - Schenectady NY

A61B 500

600549

An in situ breast tumor temperature profile measuring probe includes a rod, thermal sensors and electrical output leads. The thermal sensors are formed in spaced apart holes in an outer insulating layer of the rod and a common electrical input lead to provide an electrical input signal to the thermal sensors is disposed below and has portions exposed at the holes and electrically connected to the thermal sensors. The thermal sensors receive the electrical input signal from the common electrical input lead, sense the temperature of biological matter adjacent to the thermal sensors and produce an electrical output signal correlated thereto. Each electrical output lead mounted to the outer insulating layer is in electrical contact with a different one of the thermal sensors to receive the electrical output signal from the one thermal sensor and output the same.

6470204, Oct 22, 2002

Jul 3, 2000

09/609899

Egidijus Edward Uzgiris - Schenectady NY, 12309
Kenneth William Rohling - Burnt Hills NY, 12027
Ronald Dean Watkins - Niskayuna NY, 12309
Robert David Darrow - Scotia NY, 12302
Charles Lucian Dumoulin - Ballston Lake NY, 12019
Randy Otto John Giaquinto - Burnt Hills NY, 12027
Michael Edward Moran - Albany NY, 12203

A61B 505

600411, 600417, 600424, 606130

An insertable intracavity probe for use in Magnetic Resonance Imaging (MRI) and therapy of a region of interest proximal to a cavity, the probe having a substantially rigid probe shell for insertion into the cavity. The probe shell is adapted to incorporate at least one device for imaging the region of interest. A guide track is incorporated in the probe shell and is adapted to guide at least one biopsy or therapy device to the region of interest during imaging. Intracavity regions include cervical, rectal, and other regions associated with internal cavities of a patient.

6537521, Mar 25, 2003

Feb 23, 2001

09/792177

Egidijus Edward Uzgiris - Schenectady NY

General Electric Company - Niskayuna NY

A61K 5100

424 173, 424 91, 424 93, 424 111, 424 165

In a method for characterizing the angiogenesis status of a tumor in a living subject, timed magnetic resonance images of the subject into whom a reptating polymer contrast agent containing chelating diethylentriaminepentacetic acid dosed with gadolinum has been introduced are obtained. At least two images taken at different times are compared in order to determine the percentage image enhancement in a tumor region of interest. A contrast agent including a reptating polymer containing technetium-99 is used with a nuclear medicine version of this technique.

6685915, Feb 3, 2004

Mar 12, 2001

09/803794

Egidijus Edward Uzgiris - Schenectady NY
Terence Barnhart - Morristown NJ

General Electric Company - Niskayuna NY

A61B 5055

424 934, 424 93, 424 936, 514 2, 514 12, 530350

Linear extended polymeric paramagnetic chelates for use as MRI contrast agents are synthesized by conjugating DTPA chelator moieties to higher than 90% of the monomer residues of the polyamino acid backbone chain. The resulting polymer can be labeled with Gd, since each chelator moiety holds a Gd ion, and the resulting conformation is of an unfolded, extended linear type, capable of entering small pores and moving around obstacles in the extracellular space of tissues. The efficient production of these extended polymers is critical for the application of such contrast agents to medical imaging. One such agent is a reptating polymer containing technetium-99.

6916290, Jul 12, 2005

Mar 5, 2002

10/090576

Kristina Helena Valborg Hedengren - Schenectady NY, US
William Paul Kornrumpf - Schenectady NY, US
Mark Lloyd Miller - Schenectady NY, US
Egidijus Edward Uzgiris - Schenectady NY, US

General Electric Company - Niskayuna NY

A61B005/00
G01K007/00

600549, 374166

An in situ breast tumor temperature profile measuring probe includes a rod, thermal sensors and electrical output leads. The thermal sensors are formed in spaced apart holes in an outer insulating layer of the rod and a common electrical input lead to provide an electrical input signal to the thermal sensors is disposed below and has portions exposed at the holes and electrically connected to the thermal sensors. The thermal sensors receive the electrical input signal from the common electrical input lead, sense the temperature of biological matter adjacent to the thermal sensors and produce an electrical output signal correlated thereto. Each electrical output lead mounted to the outer insulating layer is in electrical contact with a different one of the thermal sensors to receive the electrical output signal from the one thermal sensor and output the same.

6961607, Nov 1, 2005

Jul 31, 2002

10/209989

Egidijus E. Uzgiris - Niskayuna NY, US

A61B005/05
A61B005/055

600420, 424 93

Polymeric contrast agents are used to monitor myocardial neovascularization. The agent is injected and images of the myocardium are obtained at various time intervals after injection. Localized image enhancement indicates an area of increased angiogenesis.

7901665, Mar 8, 2011

Nov 30, 2005

11/290684

Egidijus Edward Uzgiris - Schenectady NY, US
Brian James Grimmond - Clifton Park NY, US

General Electric Company - Niskayuna NY

A61K 50/00
A61M 36/14

424 111, 424 165

A method of conjugating a carboxylate-containing molecule to an amine-containing macromolecule to form a substituted macromolecule is provided. The method includes (a) forming a first solution by dissolving a substance comprising at least one macromolecule having free amine groups in an aqueous basic solution; (b) forming a second solution by combining at least one carboxylate-containing molecule with at least one acid acceptor in an aprotic solvent; (c) adding at least one carboxylate activating agent to the second solution to form an activated carboxylate-containing molecule; (d) combining the first solution and second solutions to form a multiphasic solution; and (e) isolating the resultant substituted macromolecule from the mixture. A substituted macromolecule produced by the aforementioned method is also provided. Further provided is a method of enhancing a magnetic resonance image of a subject including administering the carboxylate-containing molecule-substituted macromolecule produced by the aforementioned method.

20040022729, Feb 5, 2004

Jul 31, 2002

10/209733

Egidijus Uzgiris - Niskayuna NY, US

A61K049/04

424/009400

Sequential injections of contrast agents are employed for assessing angiogenic activity. At least one of the injections is of a polymeric contrast agent which binds to angiogenic microvasculature.