Inventors:
Clark A. Briggs - Libertyville IL, US
Murali Gopalakrishnan - Grayslake IL, US
David G. Mc Kenna - McHenry IL, US
Lisa M. Monteggia - Lindenhurst IL, US
Jean-Marc Roch - Waukegan IL, US
James P. Sullivan - Deerfield IL, US
Edward Touma - North Chicago IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
G01N 33/566
Abstract:
A variant human α7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human α7 nAChR. Nucleic acid molecules encoding the variant human α7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.