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Dyann Fergus Wirth

from Boston, MA
Age ~74

Dyann Wirth Phones & Addresses

  • 37 Hancock St, Boston, MA 02114 (617) 720-4167
  • 88 Gardiner Rd, Woods Hole, MA 02543 (617) 510-6348
  • 28 Bar Neck Rd, Woods Hole, MA 02543 (508) 457-0629 (508) 457-9761
  • 54 Gosnold Rd, Woods Hole, MA 02543 (508) 548-4178
  • Falmouth, MA

Work

Company: Harvard school of public health 2006 to 2018 Position: Chair, department of immunology and infectious diseases

Education

School / High School: The University of Freiburg Specialities: Biochemistry

Skills

Molecular Biology • Infectious Diseases • Science • Cell Biology • Genetics • Genomics • Biochemistry • Lifesciences • Western Blotting • Public Health • Cell Culture • Epidemiology • Immunology • Bioinformatics • Qpcr • Pcr • Cancer • Microscopy • Biotechnology

Industries

Research

Resumes

Resumes

Dyann Wirth Photo 1

Richard Pearson Strong Professor Of Infectious

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Location:
Boston, MA
Industry:
Research
Work:
Harvard School of Public Health 2006 - 2018
Chair, Department of Immunology and Infectious Diseases

Broad Institute 2006 - 2018
Senior Associate Member, Co-Chair, Infectious Disease Initiative at Broad Institute

2006 - 2018
Richard Pearson Strong Professor of Infectious
Education:
The University of Freiburg
Harvard University
Massachusetts Institute of Technology
Doctorates, Doctor of Philosophy, Biology, Philosophy, Biochemistry
University of Wisconsin - Madison
Bachelors, Bachelor of Science, Zoology, Chemistry
Skills:
Molecular Biology
Infectious Diseases
Science
Cell Biology
Genetics
Genomics
Biochemistry
Lifesciences
Western Blotting
Public Health
Cell Culture
Epidemiology
Immunology
Bioinformatics
Qpcr
Pcr
Cancer
Microscopy
Biotechnology

Publications

Us Patents

2-Aminoindole Compounds And Methods For The Treatment Of Malaria

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US Patent:
20120232063, Sep 13, 2012
Filed:
Oct 28, 2010
Appl. No.:
13/504635
Inventors:
Ralph Mazitschek - Arlington MA, US
Jon C. Clardy - Lamaica Plain MA, US
Dyann Wirth - Boston MA, US
Roger Wiegand - Wayland MA, US
Sameer Urgaonkar - Arlington MA, US
Mary Lynn Baniecki - Raleigh NC, US
Joseph Cortese - Quincy MA, US
Cassandra Celatka - Hull MA, US
Yibin Xiang - Acton MA, US
Renato Skerlj - Newton MA, US
Elyse M.J. Bourque - Watertown MA, US
International Classification:
A61K 31/404
C07D 405/10
C07D 413/10
A61P 33/06
C07D 491/056
A61K 31/407
C07D 403/10
A61K 31/55
C07D 209/40
A61K 31/5377
US Classification:
51421708, 548483, 514418, 548467, 544144, 5142352, 548431, 514411, 540602
Abstract:
The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the variables in Structural Formula I are defined herein.

Density-Based Separation Of Biological Analytes Using Multiphase Systems

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US Patent:
20130280693, Oct 24, 2013
Filed:
Aug 22, 2011
Appl. No.:
13/817985
Inventors:
Charles R. Mace - Auburn NY, US
Ashok A. Kumar - Cambridge MA, US
Dyann F. Wirth - Boston MA, US
George M. Whitesides - Newton MA, US
International Classification:
G01N 33/49
G01N 33/574
US Classification:
435 2, 435 34, 435 5, 435 61, 435 724
Abstract:
The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.

Small Molecule Inhibitors Of Plasmodium Falciparum Dihydroorotate Dehydrogenase

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US Patent:
20110130381, Jun 2, 2011
Filed:
May 7, 2009
Appl. No.:
12/991305
Inventors:
Cecilia Bastos - South Grafton MA, US
Michael L. Booker - Bridgewater MA, US
Cassandra A. Celatka - Hull MA, US
Jon C. Clardy - Jamaica Plain MA, US
Joseph Cortese - Quincy MA, US
Vishal P. Patel - Washington DC, US
Renato Skerlj - Newton MA, US
Roger C. Wiegand - Wayland MA, US
Dyann F. Wirth - Boston MA, US
International Classification:
A61K 31/5377
C07D 413/04
C07D 409/04
C07D 473/00
C07D 409/14
C07D 471/04
C07D 413/14
A61K 31/4025
A61K 31/4535
A61K 31/4184
A61K 31/4155
A61K 31/496
A61K 31/52
A61K 31/454
A61K 31/437
A61K 31/422
A61P 33/06
US Classification:
51421018, 544146, 548527, 546212, 5483047, 5483657, 544379, 544277, 5483061, 546199, 546118, 548217, 5483054, 548220, 5142315, 514422, 514326, 514394, 514406, 51425213, 51426323, 514322, 514303, 514375
Abstract:
Inhibitors of dihydroorotate dehydrogenase (DHODH) for the enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.

Inhibitors Of Prolyl-Trna-Synthetase

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US Patent:
20210253558, Aug 19, 2021
Filed:
Jun 10, 2019
Appl. No.:
16/973080
Inventors:
- Boston MA, US
- Cambridge MA, US
Mark A. Tye - San Ramon CA, US
N. Connor Payne - Cambridge MA, US
Dyann F. Wirth - Boston MA, US
International Classification:
C07D 403/12
C07D 241/28
C07D 401/12
C07D 405/12
C07D 401/14
A61P 33/02
Abstract:
The present application provides compounds which are inhibitors of aminoacyl tRNA-synthetase (e.g., prolyl-tRNA-synthetase) and are useful for treating disorders associated with aminoacyl tRNA-synthetase activity and/or expression. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also provided.

Density-Based Separation Of Biological Analytes Using Mutliphase Systems

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US Patent:
20180080922, Mar 22, 2018
Filed:
Nov 29, 2017
Appl. No.:
15/825706
Inventors:
- Cambridge MA, US
Ashok A. KUMAR - Medford MA, US
Dyann F. WIRTH - Boston MA, US
George M. WHITESIDES - Newton MA, US
International Classification:
G01N 33/49
G01N 33/574
G01N 33/18
G01N 33/537
B03B 5/28
B03D 3/00
B03B 5/44
Abstract:
The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.

Density-Based Separation Of Biological Analytes Using Multiphase Systems

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US Patent:
20150362477, Dec 17, 2015
Filed:
Aug 25, 2015
Appl. No.:
14/834593
Inventors:
- Cambridge MA, US
Ashok A. KUMAR - Medford MA, US
Dyann F. WIRTH - Boston MA, US
George M. WHITESIDES - Newton MA, US
International Classification:
G01N 33/49
Abstract:
The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.

Amazon

Malaria: Biology in the Era of Eradication

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Malaria affects hundreds of millions of people every year, killing several hundred thousand. This book examines the biology of the Plasmodium parasites responsible, the way the disease is transmitted via mosquitos, and current approaches to vaccination and treatment.Highlights include: - Malaria Epi...

Binding

Hardcover

Pages

300

Publisher

Cold Spring Harbor Laboratory Press

ISBN #

1621821226

EAN Code

9781621821229

ISBN #

1

Synthesis and processing of the Sindbis virus structural proteins (Massachusetts Institute of Technology. Dept. of Biology. Thesis. 1978. Ph. D)

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Author

Dyann Fergus Wirth

Binding

Unknown Binding

ISBN #

7

Malaria Gordon Conference

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Author

Dyann F. Wirth

Binding

Paperback

Publisher

PN

ISBN #

5

New Strategies for Drug Discovery and Development for Plasmodium Falciparum

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Author

Dyann F. Wirth

Binding

Paperback

Publisher

PN

ISBN #

4

New Drugs and Drug Resistance in Malaria: Molecular Genetic Analysis

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Author

Dyann F. Wirth

Binding

Paperback

Publisher

PN

ISBN #

3

Mechanisms of Drug Resistance in Plasmodium Falciparum

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Author

Dyann F. Wirth

Binding

Paperback

Publisher

PN

ISBN #

2

Dyann Fergus Wirth from Boston, MA, age ~74 Get Report