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Douglas A Lauffenburger

from Cambridge, MA
Age ~72
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Also known as:
Douglas Dr Lauffenburger, Douglas A Lauffenburge, Douglas A Lauffenburg, Doug A Griffith, Douglas G, Douglas R
Phone and address:
110 Antrim St, Cambridge, MA 02139
Related to:
Vonetta S Ray, 50
Connected to:
Dallis A Lauffenburger, 61Kenneth A Lauffenburger, 67Sarah E Lauffenburger, 47Benjamin T Lauffer, 38Bill L Lauffer, 47Darin R Lauffer, 46Dennis J Lauffer, 55Gerald C Lauffer, 69Valerie M Lauffer, 51Alan K Laufman, 76

Douglas Lauffenburger Phones & Addresses

  • 110 Antrim St, Cambridge, MA 02139
  • 26 Shepard St, Cambridge, MA 02138 (617) 661-3795
  • 26 Shepard St #E2, Cambridge, MA 02138 (617) 565-2762
  • 60 Wadsworth St #B, Cambridge, MA 02142
  • Champaign, IL
  • Taylorville, IL
  • Springfield, IL
  • 41 Turning Mill Rd, Lexington, MA 02420 (610) 565-2762
  • Media, PA

Work

Company: Massachusetts institute of technology (mit) 1998 Position: Professor and department head, biological engineering

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Minnesota 1975 to 1979 Specialities: Chemical Engineering

Skills

Bioengineering • Systems Biology • Computational Biology • Cell Biology • Biophysics • Biochemistry • Biotechnology • Cancer • Immunology

Industries

Higher Education

Resumes

Resumes

Douglas Lauffenburger Photo 1

Professor And Department Head, Biological Engineering

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Location:
Cambridge, MA
Industry:
Higher Education
Work:
Massachusetts Institute of Technology (Mit)
Professor and Department Head, Biological Engineering
University of Illinois at Urbana-Champaign 1990 - 1994
Professor
University of Pennsylvania 1979 - 1989
Assistant and Associate and Full Professor
Education:
University of Minnesota 1975 - 1979
Doctorates, Doctor of Philosophy, Chemical Engineering University of Illinois at Urbana - Champaign 1971 - 1975
Bachelors, Bachelor of Science, Chemical Engineering
Skills:
Bioengineering
Systems Biology
Computational Biology
Cell Biology
Biophysics
Biochemistry
Biotechnology
Cancer
Immunology

Publications

Us Patents

G-Csf Analog Compositions And Methods

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US Patent:
6946548, Sep 20, 2005
Filed:
Sep 10, 2001
Appl. No.:
09/950123
Inventors:
Casim A. Sarkar - Cambridge MA, US
Douglas A. Lauffenburger - Cambridge MA, US
Bruce Tidor - Lexington MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K038/19
US Classification:
530399, 435 695, 424 851
Abstract:
The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.

Methods Of Using G-Csf Analog Compositions

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US Patent:
7371370, May 13, 2008
Filed:
Aug 3, 2004
Appl. No.:
10/910087
Inventors:
Casim A. Sarkar - Cambridge MA, US
Douglas A. Lauffenburger - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 38/19
US Classification:
424 851, 514 2, 514 8, 514 12
Abstract:
The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.

Methods Of Using G-Csf Analog Compositions

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US Patent:
7402304, Jul 22, 2008
Filed:
Jan 31, 2005
Appl. No.:
11/047064
Inventors:
Casim A. Sarkar - Cambridge MA, US
Douglas A. Lauffenburger - Cambridge MA, US
Bruce Tidor - Lexington MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 38/19
US Classification:
424 851, 435 695, 530399
Abstract:
The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.

Mutant Interleukin-2 (Il-2) Polypeptides

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US Patent:
7569215, Aug 4, 2009
Filed:
Jul 19, 2004
Appl. No.:
10/894833
Inventors:
K. Dane Wittrup - Chestnut Hill MA, US
Balaji M. Rao - Cambridge MA, US
Douglas A. Lauffenburger - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07K 14/55
A61K 38/20
US Classification:
424 852, 530351, 530402
Abstract:
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.

Mutant Interleukin-2 (Il-2) Polypeptides

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US Patent:
7951360, May 31, 2011
Filed:
Aug 4, 2009
Appl. No.:
12/535083
Inventors:
K. Dane Wittrup - Chestnut Hill MA, US
Balaji M. Rao - Cambridge MA, US
Douglas A. Lauffenburger - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07K 14/55
A61K 38/20
US Classification:
424 852, 530351, 530402
Abstract:
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.

Mutant Interleukin-2 (Il-2) Polypeptides

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US Patent:
8349311, Jan 8, 2013
Filed:
Apr 15, 2011
Appl. No.:
13/088045
Inventors:
Karl Dane Wittrup - Chestnut Hill MA, US
Balaji M. Rao - Cambridge MA, US
Douglas A. Lauffenburger - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 38/20
C07K 14/55
US Classification:
424 852, 530351, 530402
Abstract:
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.

G-Csf Analog Compositions And Methods

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US Patent:
20020151488, Oct 17, 2002
Filed:
Sep 10, 2001
Appl. No.:
09/950473
Inventors:
Casim Sarkar - Cambridge MA, US
Douglas Lauffenburger - Cambridge MA, US
International Classification:
A61K038/18
C07K014/475
A61K038/20
C07H021/04
C12P021/02
C12N005/06
US Classification:
514/012000, 424/085200, 530/399000, 536/023500, 435/069100, 435/325000, 435/320100
Abstract:
The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.

Use Of Bayesian Networks For Modeling Cell Signaling Systems

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US Patent:
20070009923, Jan 11, 2007
Filed:
Jan 24, 2006
Appl. No.:
11/338957
Inventors:
Garry Nolan - San Francisco CA, US
Omar Perez - San Francisco CA, US
Karen Sachs - Cambridge MA, US
Douglas Lauffenburger - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
The Board of Trustees of the Leland Stanford Jonior University - Palo Alto CA
International Classification:
C12Q 1/68
G06F 19/00
US Classification:
435006000, 702020000
Abstract:
Methods of developing and using models of cellular networks by applying a probabilistic graphical model are provided.

Isbn (Books And Publications)

Receptors: Models for Binding, Trafficking, and Signalling

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Author

Douglas A. Lauffenburger

ISBN #

0195064666

Receptors: Models for Binding, Trafficking, and Signaling

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Author

Douglas A. Lauffenburger

ISBN #

0195106636

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Douglas A Lauffenburger from Cambridge, MA, age ~72 Get Report