Inventors:
Kelly Martin - Cincinnati OH, US
Susan Criss - Maineville OH, US
Douglas Gledhill - Cincinnati OH, US
Aloysius Ononye - Loveland OH, US
Assignee:
The Procter & Gamble Company - Cincinnati OH
International Classification:
A61K 31/616
A61K 31/55
A61K 31/522
A61K 31/519
A61K 31/485
A61K 31/192
A61K 31/16
A61K 31/137
US Classification:
424464000, 514165000, 514217000, 514217050, 514282000, 514649000, 514263310, 514630000, 514569000, 514570000, 514290000, 514420000, 514731000, 514262100, 514304000, 514729000
Abstract:
Disclosed are compositions including phenylephrine, its salts, and mixtures thereof, in combination with acetaminophen; and optionally in combination with additional pharmaceutical actives. The compositions have a pH of about 6.5 to about 7.5 and may be substantially free of aldehydes. The invention also provides a method of stabilizing phenylephrine. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its salts, and mixtures thereof, in combination with acteaminophen; and optionally in combination with additional pharmaceutical actives, wherein the composition has a pH of from about 6.5 to about 7.5 and may be substantially free of aldehydes.