- Madison WI, US Fan Zhang - Madison WI, US Douglas Braun - Mount Horeb WI, US Gene Ananiev - Middleton WI, US F. Michael Hoffmann - Madison WI, US
International Classification:
C07D 239/22
Abstract:
The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-β signaling and/or TGF-β induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-β signaling and/or EMT.
Biemamides And Related Scaffolds As Inhibitors Of Transforming Growth Factor-Beta Signaling
- Madison WI, US Fan Zhang - Madison WI, US Douglas Braun - Mount Horeb WI, US Gene Ananiev - Middleton WI, US F. Michael Hoffmann - Madison WI, US
International Classification:
C07D 239/22
Abstract:
The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-β signaling and/or TGF-β induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-β signaling and/or EMT.
Forazolines, Compositions Thereof And Uses Thereof
- Madison WI, US Thomas WYCHE - Madison WI, US David ANDES - Madison WI, US Douglas BRAUN - Mount Horeb WI, US
International Classification:
C07D 513/18 A61K 31/7048 A61K 31/429
US Classification:
514 31, 548149, 514366
Abstract:
An isolated compound of Formula I and salts thereof are provided:wherein X is Cl or Br. A compound isolated from and having a chemical formula of CHClNOSor CHBrNOSis also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as are also disclosed.
