Inventors:
Raymond E. Counsell - Ann Arbor MI
Marc A. Longino - Ann Arbor MI
Jamey P. Weichert - Ann Arbor MI
Douglas A. Bakan - San Diego CA
Assignee:
The Board of Regents acting for and on behalf of the University of
Michigan - Ann Arbor MI
International Classification:
A61K 5112
A61K 4904
A61K 9107
B01F 300
Abstract:
A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell-selective delivery vehicle. Radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate] or 2-oleoylglycerol-1,3-bis[. omega. -(3,5-bis-trifluoromethyl)-heptanoate] or phenyl acetate, can be incorporated into the lipophilic core of a lipoprotein-like emulsion particle. The lipophilic core is surrounded by a phospholipid membrane comprising cholesterol and apolipoproteins. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm as measured by number weighting analysis with a narrow size distribution (