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Donnette Daley Staas

from Harleysville, PA
Age ~54
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Also known as:
Donnette D Staas, Donnette C Staas, Donnette C Daley
Phone and address:
505 Creekview Dr, Harleysville, PA 19438
(215) 256-8942
Related to:
Jilda Cusick
Connected to:
Ellen E Staas, 35Jay K Staas, 67Lois A Staas, 70Sandra L Staas, 62Eric J Staat, 42Eugene G Staat, 70Jennie V Staat, 112Julie E Staat, 81Sharon A Staat, 80Shelly R Staat, 60

Donnette Staas Phones & Addresses

  • 505 Creekview Dr, Harleysville, PA 19438 (215) 256-8942 (215) 412-2274
  • Bristol, PA
  • Cambridge, MA
  • Lansdale, PA
  • North Kingstown, RI
  • Boston, MA
  • Montgomery, PA
  • 505 Creekview Dr, Harleysville, PA 19438 (215) 256-8942

Work

Company: Merck Nov 2018 Position: Executive director, global regulatory affairs and clinical safety

Education

Degree: Master of Science, Masters School / High School: Temple University 2009 to 2011

Skills

Drug Discovery • Medicinal Chemistry • Chemistry • Synthetic Organic Chemistry • Molecular Modeling • Organic Chemistry • Cheminformatics • Drug Design • Drug Development • Organic Synthesis • Regulatory Affairs • Pharmaceutical Industry • Biotechnology • Life Sciences • Clinical Development

Languages

Spanish • German

Industries

Pharmaceuticals

Resumes

Resumes

Donnette Staas Photo 1

Executive Director, Global Regulatory Affairs And Clinical Safety

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Location:
505 Creekview Dr, Harleysville, PA 19438
Industry:
Pharmaceuticals
Work:
Merck
Executive Director, Global Regulatory Affairs and Clinical Safety
Merck
Senior Principal Scientist, Regulatory Liaison, Director, Worldwide Regulatory Liaison
Merck Jun 2006 - Mar 2012
Senior Research Fellow
Merck Jun 2002 - May 2006
Research Fellow
Merck Feb 1998 - May 2002
Senior Research Chemist
Education:
Temple University 2009 - 2011
Master of Science, Masters Harvard University 1992 - 1998
Doctorates, Masters, Master of Arts, Doctor of Philosophy, Chemistry Columbia University In the City of New York 1988 - 1992
Bachelors, Bachelor of Arts, Chemistry
Skills:
Drug Discovery
Medicinal Chemistry
Chemistry
Synthetic Organic Chemistry
Molecular Modeling
Organic Chemistry
Cheminformatics
Drug Design
Drug Development
Organic Synthesis
Regulatory Affairs
Pharmaceutical Industry
Biotechnology
Life Sciences
Clinical Development
Languages:
Spanish
German

Business Records

Name / Title
Company / Classification
Phones & Addresses
Donnette Staas
Principal
Staas Donnette
Business Services at Non-Commercial Site
505 Creekview Dr, Harleysville, PA 19438

Publications

Us Patents

Thrombin Inhibitors

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US Patent:
6515011, Feb 4, 2003
Filed:
Dec 18, 2001
Appl. No.:
10/023776
Inventors:
Harold G. Selnick - Ambler PA
James C. Barrow - Harleysville PA
Philippe G. Nantermet - Lansdale PA
Peter D. Williams - Harleysville PA
Kenneth J. Stauffer - Souderton PA
Philip E. Sanderson - Philadelphia PA
Kenneth E. Rittle - Green Lane PA
Matthew M. Morrissette - Pottstown PA
Catherine M. Wiscount - Allentown PA
Lekhanh O. Tran - Norristown PA
Terry A. Lyle - Lederach PA
Donnette D. Staas - Harleysville PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3140
US Classification:
514423, 548538, 548528, 548518, 546111, 5462791, 514422, 514343, 514290
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. where R is âCH NH , âCH CH NH , or âCH NHC(O)OC(CH ).

Thrombin Inhibitors

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US Patent:
6528503, Mar 4, 2003
Filed:
Jun 14, 2002
Appl. No.:
10/171708
Inventors:
Peter D. Williams - Harleysville PA
Terry A. Lyle - Lederach PA
Matthew M. Morrissette - Pottstown PA
Lekhanh O. Tran - Norristown PA
Donnette D. Staas - Harleysville PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 31397
US Classification:
514210, 548953, 5462681, 514340
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclopropyl-3-methyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide.

Thrombin Inhibitors

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US Patent:
6610692, Aug 26, 2003
Filed:
Oct 28, 1999
Appl. No.:
09/429741
Inventors:
Philip E. Sanderson - Philadelphia PA
Bruce D. Dorsey - Maple Glen PA
Terry A. Lyle - Lederach PA
Matthew G. Stanton - North Wales PA
Donnette Staas - Lansdale PA
Craig Coburn - Skippack PA
Matthew M. Morrissette - Pottstown PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 31497
US Classification:
514248, 544405, 544236, 51425505, 514300, 514303, 514337, 514338, 514339, 546113, 546117, 546118, 546119, 546122, 5462684, 5462721, 5462734, 5462757, 5462771, 5462774
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY or N; d is CY or N; e is CY or N; f is CY or N; g is CY or N; Y , Y , and Y are independently hydrogen, C alkyl, or halogen; Y and Y are independently hydrogen, C alkyl, C cycloalkyl, halogen, NH , OH or C alkoxy, and Y is hydrogen, C alkyl, C cycloalkyl, halogen, âCN, NH , OH or C alkoxy; A is and W, W , R , R , R , R , X and Z are defined in the specification.

Thrombin Inhibitors

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US Patent:
7144899, Dec 5, 2006
Filed:
Feb 5, 2002
Appl. No.:
10/467439
Inventors:
Harold G. Selnick - Ambler PA, US
Mary Beth Young - Lansdale PA, US
Philippe G. Nantermet - Lansdale PA, US
James C. Barrow - Harleysville PA, US
Peter D. Williams - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Donnette D. Staas - Harleysville PA, US
Kenneth J. Stauffer - Souderton PA, US
Philip E. Sanderson - Philadelphia PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/4439
C07D 401/12
US Classification:
514340, 514361, 5462687, 5462691, 548127, 548131, 548134
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R)CH(R)— wherein the nitrogen atom is attached to R, and Rand Rare independently selected from the group consisting of hydrogen, Ccycloalkyl, and Calkyl, or 2) wherein the nitrogen atom is attached to R, and m is 0, 1, or 2.

Hydroxy Pyridopyrrolopyrazine Dione Compounds Useful As Hiv Integrase Inhibitors

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US Patent:
7435735, Oct 14, 2008
Filed:
Oct 18, 2004
Appl. No.:
10/576328
Inventors:
John S. Wai - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Linghang Zhuang - Chalfont PA, US
Donnette D. Staas - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Boyoung Kim - Lansdale PA, US
Mark W. Embrey - North Wales PA, US
Catherine M. Wiscount - Allentown PA, US
Lekhanh O. Tran - Norristown PA, US
Melissa Egbertson - Ambler PA, US
Kelly L. Savage - Schwenksville PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 471/00
C07D 487/00
C07D 241/36
US Classification:
514250, 544345
Abstract:
Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R, R, R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Hiv Integrase Inhibitors

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US Patent:
7538112, May 26, 2009
Filed:
May 3, 2005
Appl. No.:
11/579772
Inventors:
John S. Wai - Harleysville PA, US
Joseph P. Vacca - Telford PA, US
Linghang Zhuang - Chalfont PA, US
Boyoung Kim - Lansdale PA, US
Terry A. Lyle - Lederach PA, US
Catherine M. Wiscount - Allentown PA, US
Melissa S. Egbertson - Ambler PA, US
Lou Anne Neilson - Sellersville PA, US
Mark Embrey - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Donnette D. Staas - Harleysville PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 487/14
A61K 31/5025
A61K 31/4985
US Classification:
514250, 544234
Abstract:
Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R, R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Hiv Integrase Inhibitors

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US Patent:
7820680, Oct 26, 2010
Filed:
Mar 4, 2005
Appl. No.:
10/592222
Inventors:
Peter D. Williams - Harleysville PA, US
John S. Wai - Harleysville PA, US
Mark W. Embrey - Harleysville PA, US
Donnette D. Staas - Harleysville PA, US
Linghang Zhuang - Chalfont PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/519
US Classification:
5142591, 544256, 544350
Abstract:
Bicyclic uracils and related compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the compounds are of Formula I:.

1-Hydroxy Naphthyridine Compounds As Anti-Hiv Agents

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US Patent:
20100056516, Mar 4, 2010
Filed:
Jul 13, 2007
Appl. No.:
12/373907
Inventors:
Peter D. Williams - Harleysville PA, US
Shankar Venkatraman - Lansdale PA, US
H. Marie Langford - Phoenixville PA, US
Boyoung Kim - Lansdale PA, US
Theresa M. Booth - Warminster PA, US
Jay A. Grobler - Gwynedd PA, US
Donnette Staas - Harleysville PA, US
Rowena D. Ruzek - North Wales PA, US
Mark W. Embrey - Harleysville PA, US
Catherine M. Wiscount - Allentown PA, US
Terry A. Lyle - Port Townsend WA, US
International Classification:
A61K 31/4375
C07D 471/04
C07D 413/14
A61K 31/5377
A61P 31/18
US Classification:
5142345, 546123, 544127, 514300
Abstract:
1-Hydroxy naphthyridine compounds (e.g., 1-hydroxy naphthyridin-2(1H)-one compounds of Formula I are inhibitors of HIV integrase and/or HIV RNase H and inhibitors of HIV replication: (I) wherein X and R1-R6 are as defined herein. The compounds are useful in the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other anti-HIV agents such as HIV antivirals, immunomodulators, antibiotics and vaccines.
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Donnette Daley Staas from Harleysville, PA, age ~54 Get Report