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Donn N Rubingh

from Cincinnati, OH
Age ~79
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Also known as:
Donn Nelton Rubingh, Don N Rubingh, Donn N Rubling, Donn Rubinch
Phone and address:
8224 Sheed Rd, Cincinnati, OH 45247
(513) 385-3943
Related to:
Maria N Mullin, 49Douglas J Rubingh, 54Ruth J Rubingh, 79Penelope G Bernard, 88Michael J Rubingh, 59James Bernard, 59Jennifer B Rubingh, 52Maria N Rubingh, 48
Connected to:
Joseph Rubini, 64Darrell A Rubink, 74Adam J Rubino, 39Alison M Rubino, 44Amalia Rubino, 28Amy M Rubino, 48Angelina Rubino, 95Anthony M Rubino, 74Carla Rubino, 46Cathleen A Rubino, 61

Donn Rubingh Phones & Addresses

  • 8224 Sheed Rd, Cincinnati, OH 45247 (513) 385-3943
  • Colerain Township, OH
  • Hamilton, OH

Work

Company: Procter & gamble 1996 to 2001 Position: Research fellow

Education

Degree: Ph-D School / High School: University of Wisconsin-Madison 1968 to 1973 Specialities: Chemistry

Industries

Chemicals

Resumes

Resumes

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Donn Rubingh

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Location:
Cincinnati, OH
Industry:
Chemicals
Work:
Procter & Gamble 1996 - 2001
Research Fellow
Education:
University of Wisconsin-Madison 1968 - 1973
Ph-D, Chemistry

Publications

Us Patents

Bpn′ Variants Having Decreased Adsorption And Increased Hydrolysis Wherein One Or More Loop Regions Are Substituted

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US Patent:
6436690, Aug 20, 2002
Filed:
Mar 3, 1995
Appl. No.:
08/394011
Inventors:
Bobby Lee Barnett - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Chanchal Kumar Ghosh - West Chester OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 956
US Classification:
435222, 435 691, 4352523, 4353201, 435471, 510392, 536 232
Abstract:
The present invention relates to subtilisin BPNâ variants having a modified amino acid sequence of wild-type BPNâ amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region and a fifth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin BPNâ (i. e. , substitution) at specifically identified positions in one or more of the loop regions whereby the BPNâ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin BPNâ. The present invention also relates to the genes encoding such subtilisin BPNâ variants. The present invention also relates to compositions comprising such subtilisin BPNâ variants for cleaning a variety of surfaces.

Bpn′ Variants Having Decreased Adsorption And Increased Hydrolysis

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US Patent:
6440717, Aug 27, 2002
Filed:
Mar 2, 1995
Appl. No.:
08/397329
Inventors:
Bobby Lee Barnett - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Chanchal Kumar Ghosh - West Chester OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 956
US Classification:
435222, 435 691, 43525235, 4353201, 435471, 536 232, 510320, 510374, 510392
Abstract:
The present invention relates to subtilisin BPNâ variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPNâ (i. e. , substitution) at specifically identified positions, whereby the BPNâ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPNâ. The present invention further relates to various cleaning compositions comprising such BPNâ variants.

Proteinase K Variants Having Decreased Adsorption And Increased Hydrolysis

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US Patent:
6451574, Sep 17, 2002
Filed:
Sep 23, 1997
Appl. No.:
08/935887
Inventors:
Bobby Lee Barnett - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 958
US Classification:
435219, 435 691, 4352523, 4353201, 435471, 510392, 536 232
Abstract:
The present invention relates to Proteinase K variants having a modified amino acid sequence of wild-type Proteinase K amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Proteinase K (i. e. , substitution) at specifically identified positions in one or more of the loop regions whereby the Proteinase K variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Proteinase K. The present invention also relates to DNA sequences encoding such Proteinase K variants. The present invention also relates to compositions comprising such Proteinase K variants for cleaning a variety of surfaces.

Subtilisin Carlsberg Variants Having Decreased Adsorption And Increased Hydrolysis

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US Patent:
6455295, Sep 24, 2002
Filed:
Mar 8, 1995
Appl. No.:
08/400698
Inventors:
Bobby Lee Barnett - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 956
US Classification:
435221, 435 691, 4352523, 4353201, 435471, 510392, 536 232
Abstract:
The present invention relates to subtilisin Carlsberg variants having a modified amino acid sequence of wild-type subtilisin Carlsberg amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin Carlsberg (i. e. , substitution) at specifically identified positions in one or more of the loop regions whereby the subtilisin Carlsberg variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin Carlsberg. The present invention also relates to the genes encoding such subtilisin Carlsberg variants. The present invention also relates to compositions comprising such subtilisin Carlsberg variants for cleaning a variety of surfaces.

Subtilisin Dy Variants Having Decreased Adsorption And Increased Hydrolysis

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US Patent:
6475765, Nov 5, 2002
Filed:
Mar 9, 1995
Appl. No.:
08/401575
Inventors:
Bobby Lee Barnett - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Assignee:
Procter Gamble Company - Cincinnati OH
International Classification:
C12N 956
US Classification:
435221, 435 691, 4352523, 4353201, 435471, 510392, 536 232
Abstract:
The present invention relates to Subtilisin DY variants having a modified amino acid sequence of wild-type Subtilisin DY amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Subtilisin DY (i. e. , substitution) at specifically identified positions in one or more of the loop regions whereby the Subtilisin DY variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Subtilisin DY. The present invention also relates to DNA sequences encoding such Subtilisin DY variants. The present invention also relates to compositions comprising such Subtilisin DY variants for cleaning a variety of surfaces.

Proteases Having Modified Amino Acid Sequences Conjugated To Addition Moieties

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US Patent:
6495136, Dec 17, 2002
Filed:
Jun 2, 1998
Appl. No.:
09/088912
Inventors:
David John Weisgerber - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Paul Elliott Correa - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
A61K 3848
US Classification:
424 9464, 424401, 424 701, 424 9463, 435177, 435178, 435180, 435188, 435219, 435221, 510392
Abstract:
Protease conjugates such as subtilisin conjugates are provided comprising a protease moiety and one or more addition moieties wherein the protease moiety has a modified amino acid sequence of a parent amino acid sequence. The parent amino acid sequence comprises a first epitope region, a second epitope region and a third epitope region, and the modified amino acid sequence comprises a substitution by a substituting amino acid at one or more positions in one or more of the epitope regions. When a substitution occurs in the first epitope region, the substitution occurs at one or more positions corresponding to positions 70-84 of subtilisin BPNâ. When a substitution occurs in the second epitope region, the substitution occurs at one or more positions corresponding to positions 103-126 of subtilisin BPNâ. When a substitution occurs in the third epitope region, the substitution occurs at one or more positions corresponding to positions 217-252 of subtilisin BPNâ. Each addition moiety is covalently attached to one of the substituting amino acids.

Protease Conjugates Having Sterically Protected Clip Sites

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US Patent:
6566115, May 20, 2003
Filed:
Jul 18, 2000
Appl. No.:
09/618740
Inventors:
David John Weisgerber - Cincinnati OH
Donn Nelton Rubingh - Cincinnati OH
Paul Elliott Correa - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 954
US Classification:
435221, 435 691, 435222, 4352523, 4353201, 435471, 510350, 524267, 536 232
Abstract:
The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to a clip site protection position of the protease moiety, wherein the clip site protection positions are selected from 13, 14, 15, 16, 18, 19, 20, 21, 84, 85, 88, 158, 159, 160, 161, 162, 163, 164, 165, 170, 186, 191, 192, 193, 194, 196, 259, 260, 261, 262, and 274 corresponding to subtilisin BPNâ. The protease conjugates have decreased immunogenicity relative to a parent protease. The present disclosure further relates to cleaning and personal care compositions comprising the protease conjugates.

Serine Protease Variants Having Amino Acid Substitutions

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US Patent:
6569663, May 27, 2003
Filed:
Sep 25, 2000
Appl. No.:
09/646982
Inventors:
Donn Nelton Rubingh - Cincinnati OH
Elizabeth Ellen Sikorski - Fairfield OH
Paul Elliott Correa - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C12N 954
US Classification:
435221, 435 691, 435222, 4352523, 4353201, 435471, 510350, 524267, 536232
Abstract:
The present invention relates to variants of serine proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a substitution of one or more specifically identified positions corresponding to subtilisin BPNâ. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.

Isbn (Books And Publications)

Polymer Solutions, Blends, and Interfaces: Proceedings of the Procter and Gamble Uerp Symposium

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Author

Donn N. Rubingh

ISBN #

0444893970

Cationic Surfactants: Physical Chemistry

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Author

Donn N. Rubingh

ISBN #

0824783573

Mixed Surfactant Systems: Developed from a Symposium at the 65th Colloid and Surface Science Symposium, Norman, Oklahoma, June 17-19, 1991

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Author

Donn N. Rubingh

ISBN #

0841224684

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Donn N Rubingh from Cincinnati, OH, age ~79 Get Report