Donald D Sleeter

47847387, Nov 15, 1988

Dec 12, 1985

6/808307

Donald D. Sleeter - Berkeley CA
George G. Fernwood - San Anselmo CA
Samuel Burd - Oakland CA

Bio-Rad Laboratories, Inc. - Hercules CA

G01N 2728
G01N 2726

2041828

A gel used for electrophoresis is cast in a gel enclosure in which the gel will ultimately be used during the electrophoresis, by a novel method and using novel apparatus which provide for quick assembly and avoidance of leaks. The method and apparatus involve a wettable, preferably porous, membrane such as filter paper, which is thoroughly wetted with gel forming solution, then placed over the bottom opening of the gel enclosure and held in place until the gel on the membrane sets. Sealing of any cracks, gaps or irregularities along the rim of the opening is thereby achieved by the capillary action of the gel forming solution. The enclosure itself is then filled with gel forming solution. Once the latter has set, the membrane is removed.

56664354, Sep 9, 1997

Dec 9, 1994

8/354412

Dean S. Burgi - Menlo Park CA
Daniel M. Bartell - Foster City CA
Donald D. Sleeter - San Leandro CA
Lucina P. Mastro - San Francisco CA

Genomyx Corporation - Foster City CA

G06K 900

382129

A system for identification of DNA bases in a nucleotide sequence includes a microprocessor and a set of executable instructions and is configured to accept a set of input data corresponding to a DNA sequence image from an autoradiograph. In part by interpolating a distribution of density peaks derived from the set of input data, the system is configured to generate a set of output data substantially identifying or presenting the bases in the DNA sequence in a linear fashion, corresponding to the linear order of nucleotides comprising the DNA sequence. The system thereby enables identification of substantially more bases than could be read by the human eye. Enhanced electrophoresis equipment and consumables may also be applied to generate a more predictable and linear set of input data and, in turn, to generate a set of output data identifying an even greater number of DNA bases in the sequence under analysis.

46630155, May 5, 1987

Sep 30, 1985

6/782756

Donald D. Sleeter - Berkeley CA
Raymond D. von Alven - San Rafael CA
George G. Fernwood - San Anselmo CA

Bio-Rad Laboratories, Inc. - Richmond CA

B01D 1302

204299R

An integrated plate structure provides a novel component for use in an electrophoretic sequencing cell. The integrated plate structure consists of a glass plate and a plastic plate bonded together along a raised edge of the latter, the edge extending along the sides and bottom of the plastic plate. The plates thus form a permanent enclosure for an upper buffer solution, open at the top for filling. The glass plate further serves as one of the two glass plates forming the gel enclosure.