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Diwahar L Narasimhan

from Folsom, CA
Age ~52
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Also known as:
Diwakar L Narasimhan, Diwahar Narasinhan, Diwakar Narasimham
Related to:
Florence Rourke, 75
Connected to:
Alamelu V Narasimhan, 70Ashwin K Narasimhan, 33Avinash Narasimhan, 45Balasubramanian Narasimhan, 48Deepa Narasimhan, 57Deepika Narasimhan, 43Geetha L Narasimhan, 64Geethanjali Narasimhan, 55Govindarajan Narasimhan, 37Hema Narasimhan, 39

Diwahar Narasimhan Phones & Addresses

  • Folsom, CA
  • 10973 Northsky Sq, Cupertino, CA 95014
  • South Portland, ME
  • Ypsilanti, MI
  • 3515 Green Brier Blvd, Ann Arbor, MI 48105 (734) 995-5808
  • 3033 Woodland Hills Dr, Ann Arbor, MI 48108 (734) 975-4089
  • Toledo, OH
  • 3033 Woodland Hills Dr, Ann Arbor, MI 48108 (734) 502-1083

Work

Company: Upjohn center for depression, university of michigan 2010 Position: Research fellow

Education

School / High School: Univ of Michigan 2010 Specialities: Research Fellowship

Skills

Protein engineering using structure-base... • Expertise in PyMol • Swiss-PDB and Expasy software • Protein modifications such as PEGylation • albumination • X-ray crystallography of proteins • Mass-spec analysis of proteins • 2D-gel electrophoresis and IEF • Viral gene therapy techniques • which include adenoviral and AAV-based v... • Molecular cloning expertise • Scale-up protein manufacturing and purif... • Advanced cell culture techniques includi... • mammalian • insect and yeast cells • Fermenter/Bio-reactor utilization to exp... • Enzyme kinetics • Advanced microscopy techniques.

Languages

Tamil • Kannada • Hindi

Awards

Special session speaker invite - Pharmac... • Speaker invitation - International bioan... • Speaker invitation - National biotechnol... • Speaker invitation - Experimental biolog... • Travel award - American society of virol... • Pre-doctoral travel award - American soc...

Industries

Research

Resumes

Resumes

Diwahar Narasimhan Photo 1

Experienced Protein Chemist, University Of Michigan

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Position:
UpJohn Center Research Fellow at University of Michigan
Location:
Ann Arbor, Michigan
Industry:
Research
Work:
University of Michigan - University of Michigan since 2010
UpJohn Center Research Fellow
University of Michigan Medical School - Ann Arbor, MI, USA 2003 - 2009
Post Doctoral fellow
Medical College of Ohio, University of Toledo - Toledo, Ohio Area Aug 1995 - Dec 2001
Pre-Doctoral Fellow
Education:
University of Toledo 1995 - 2001
PhD, Life Sciences Birla Institute of Technology and Science 1989 - 1994
M.Sc & B.Pharm, Bio & Pharm
Languages:
Tamil
Kannada
Hindi
Awards:
Special Session Speaker Invite
Pharmacokinetic Approaches to Treatment of Drug Abuse Symposium, Experimental Biology 2011, Washington, DC
Speaker Invitation
International Bioanalytical Congress, Belgium.
Speaker Invitation
National Biotechnology Conference, Seattle
Invited to speak in a special session dealing with Protein Biologic based therapy for Drug abuse.
Speaker Invitation
Experimental Biology Meeting 2008, San Diego, CA
Invited speaker at the Experimental Biology Meeting 2008, San Diego, CA.
Travel Award
American Society of Virology Annual Meeting, UC Davis, California
Pre-doctoral Travel Award
American Society of Virology Annual Meeting, Vancouver BC
Diwahar Narasimhan Photo 2

Diwahar Narasimhan Ann Arbor, MI

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Work:
UpJohn Center for Depression, University of Michigan

2010 to 2000
Research Fellow
University of Michigan
Ann Arbor, MI
2002 to 2009
Post Doctoral Fellow
Education:
Univ of Michigan
2010 to 2000
Research Fellowship
Univ of Michigan
2002 to 2010
Doctoral in Pharmacology
University of Toledo
Toledo, OH
1995 to 2001
Ph.D. in Dept of Biochem & Mol Bio
BITS Pilani
Pilani, Rajasthan
1989 to 1994
M.Sc in Biological Sciences
BITS
Pilani, Rajasthan
1989 to 1994
B.Pharm
Skills:
Protein engineering using structure-based approaches, Expertise in PyMol, Swiss-PDB and Expasy software, Protein modifications such as PEGylation, albumination, X-ray crystallography of proteins, Mass-spec analysis of proteins, 2D-gel electrophoresis and IEF,Viral gene therapy techniques, which include adenoviral and AAV-based vectors, Molecular cloning expertise, Scale-up protein manufacturing and purification expertise, Advanced cell culture techniques including bacterial, mammalian, insect and yeast cells, Fermenter/Bio-reactor utilization to express proteins in large scale and large volume chromatography, Enzyme kinetics, Advanced microscopy techniques.

Publications

Us Patents

Anti-Cocaine Compositions And Treatment

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US Patent:
8318156, Nov 27, 2012
Filed:
Jul 10, 2007
Appl. No.:
12/373510
Inventors:
Donald W Landry - New York NY, US
Joanne MacDonald - New York NY, US
Daquan Gao - Louisville KY, US
James H. Woods - Ann Arbor MI, US
Roger K. Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
University of Kentucky Research Foundation - Lexington KY
International Classification:
A61K 38/46
A61K 38/43
C12N 9/16
C12N 9/14
C12P 21/06
C12P 19/34
C07H 21/04
US Classification:
424 946, 424 941, 435196, 435195, 435 691, 435 911, 536 231, 536 232, 530350
Abstract:
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Compositions And Methods For Altering Cocaine Esterase Activity

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US Patent:
8501692, Aug 6, 2013
Filed:
Dec 14, 2010
Appl. No.:
13/515511
Inventors:
Roger K. Sunahara - Ann Arbor MI, US
John J. G. Tesmer - Ann Arbor MI, US
Diwahar Narasimhan - Ypsilanti MI, US
James H. Woods - Ann Arbor MI, US
Mark R. Nance - Ann Arbor MI, US
Elin Edwald - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07K 1/00
A61K 38/00
C07H 21/04
US Classification:
514 121, 514 182, 536 232, 530350
Abstract:
The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.

Thermostabilization Of Proteins

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US Patent:
8637009, Jan 28, 2014
Filed:
Jul 10, 2008
Appl. No.:
12/667895
Inventors:
Donald W. Landry - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger K. Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Milan N. Stojanovich - Fort Lee NJ, US
John J. Tesmer - Ann Arbor MI, US
Remy L. Brim - Farmington Hills MI, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 38/46
C12N 9/96
US Classification:
424 946, 435188
Abstract:
Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

Anti-Cocaine Compositions And Treatment

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US Patent:
20130136728, May 30, 2013
Filed:
Nov 14, 2012
Appl. No.:
13/676324
Inventors:
The Trustees of Columbia University in the City of - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US
Daquan Gao - Louisville KY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 9/18
US Classification:
424 946, 536 232, 435197
Abstract:
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Thermostabilization Of Proteins

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US Patent:
20170106056, Apr 20, 2017
Filed:
Dec 25, 2016
Appl. No.:
15/390514
Inventors:
Donald W. Landry - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger K. Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Milan N. Stojanovic - Fort Lee NJ, US
John J. Tesmer - Ann Arbor MI, US
Remy L. Brim - Farmington Hills MI, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 38/46
C12N 9/18
C12Q 1/44
A61K 9/00
Abstract:
Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

Anti-Cocaine Compositions And Treatment

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US Patent:
20160160195, Jun 9, 2016
Filed:
Nov 30, 2015
Appl. No.:
14/954813
Inventors:
Donald Landry - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US
Daquan Gao - Louisville KY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
The University of Kentucky Research Foundation - Lexington KY
International Classification:
C12N 9/18
A61K 38/46
Abstract:
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Thermostabilization Of Proteins

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US Patent:
20140348813, Nov 27, 2014
Filed:
Jan 28, 2014
Appl. No.:
14/166619
Inventors:
Donald W. Landry - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger K. Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Milan N. Stojanovich - Fort Lee NJ, US
John J. Tesmer - Ann Arbor MI, US
Remy L. Brim - Farmington Hills MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61K 47/22
C12Q 1/44
A61K 47/18
A61K 38/46
A61K 47/12
US Classification:
424 946, 435 19, 506 11
Abstract:
Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.
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Diwahar L Narasimhan from Folsom, CA, age ~52 Get Report