US Patent:
20130224122, Aug 29, 2013
Inventors:
The Board of Trustees of the Leland Stanford Junior University - , US
Michael Benoit - Menlo Park CA, US
A. C. Matin - Stanford CA, US
Yoram Barak - Menlo Park CA, US
Shay Keren - Haifa, IL
Dirk Mayer - Menlo Park CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61K 49/18
Abstract:
Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. AMB-1 produces positive MRI contrast when generating ultrasmall magnetite particles (10-40 nm diameter). Positive MRI contrast permits clearer distinction from image voids compared to negative contrast. T1-weighted MRI showed that such bacteria increased positive contrast 2.2-fold (p