Inventors:
Tae-Wan Kim - East Brunswick NJ, US
Gilbert Di Paolo - Northford CT, US
Min Suk Kang - Fort Lee NJ, US
Diego Berman - New York NY, US
Laura Beth Johnson McIntire - New York NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61K 31/122
A61K 31/13
A61K 31/382
A61K 31/385
A61K 31/435
A61P 25/28
US Classification:
5142315, 5142245, 5142298, 5142312, 5142328, 514436, 514451, 514453
Abstract:
The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or “PIP2”), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with γ-secretase and lipid rafts.
