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Diane Lipscombe

from Barrington, RI
Age ~65
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Connected to:
Adrian M Lipscombe, 43Agrid F Lipscomb, 71Alonzo Lipscomb, 74Bryan P Lipscomb, 57Caitlin M Lipscomb, 33Chase D Lipscomb, 27Chavis M Lipscomb, 51Christine R Lipscombe, 72Danielle M Lipscomb, 51Denny Lipscombe, 68

Diane Lipscombe Phones & Addresses

  • 6 Watson Ave, Barrington, RI 02806 (401) 247-4897
  • Providence, RI
  • East Providence, RI
  • 6 Watson Ave, Barrington, RI 02806

Work

Company: Brown university 1990 Position: Professor of neuroscience

Education

Degree: Bachelors, Bachelor of Science

Industries

Higher Education

Resumes

Resumes

Diane Lipscombe Photo 1

Professor Of Neuroscience

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Location:
Providence, RI
Industry:
Higher Education
Work:
Brown University
Professor of Neuroscience

Publications

Us Patents

Human N-Type Calcium Channel Isoform And Uses Thereof

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US Patent:
7018832, Mar 28, 2006
Filed:
Dec 28, 2001
Appl. No.:
10/033026
Inventors:
Diane Lipscombe - Barrington RI, US
Stephanie Schorge - Smithfield RI, US
Assignee:
Brown University Research Foundation - Providence RI
International Classification:
C07H 21/04
C12N 15/11
C12N 15/85
C12N 1/20
US Classification:
4353201, 435 6, 435325, 4352523, 536 231, 536 235, 536 243
Abstract:
The invention pertains to a human N-type calcium channel isoform, hα, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human hαchannel. Also included are human N-type calcium channel hαsubunit inhibitors which inhibit human N-type calcium channel hαsubunit activity by inhibiting the expression or function of human N-type calcium channel hαsubunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e. g. , neuropathic pain, and traumatic brain injury.

Human N-Type Calcium Channel Isoform And Uses Thereof

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US Patent:
8038995, Oct 18, 2011
Filed:
Feb 7, 2006
Appl. No.:
11/350336
Inventors:
Diane Lipscombe - Barrington RI, US
Stephanie Schorge - Charvil, GB
Assignee:
Scion Pharmaceuticals, Inc. - Medford MA
International Classification:
A61K 39/00
A61K 39/395
C07K 16/00
C07K 16/18
US Classification:
4241391, 4241301, 4241331, 4241351, 4241411, 5303871, 5303879, 5303881, 5303891
Abstract:
The invention pertains to a human N-type calcium channel isoform, hα, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human hαchannel. Also included are human N-type calcium channel hαsubunit inhibitors which inhibit human N-type calcium channel hαsubunit activity by inhibiting the expression or function of human N-type calcium channel hαsubunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e. g. , neuropathic pain, and traumatic brain injury.

Nociceptive Neuron Specific Calcium Channel Isoform And Uses Thereof

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US Patent:
20040214238, Oct 28, 2004
Filed:
Dec 15, 2003
Appl. No.:
10/736883
Inventors:
Diane Lipscombe - Barrington RI, US
Andrew Castiglioni - Arlington MA, US
Thomas Bell - Turnersville NJ, US
Christopher Thaler - Newtown PA, US
Assignee:
Brown University Research Foundation - Providence RI
International Classification:
G01N033/53
G01N033/567
C12N005/08
C07K014/705
US Classification:
435/007200, 435/368000, 530/350000
Abstract:
The invention pertains to N-type calcium channel isoforms containing exon 37a (Cav2.2e[37a]), which are specifically expressed in nociceptive neurons, and nucleic acids relating thereto. Also included are methods for identifying antagonists of Cav2.2e[37a] subunit activity that act by inhibiting the expression or function of the subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitor molecules in the treatment and/or diagnosis of disease, such as in methods for treating pain, particularly neuropathic pain.

Human N-Type Calcium Channel Isoform

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US Patent:
6353091, Mar 5, 2002
Filed:
Mar 12, 1999
Appl. No.:
09/268163
Inventors:
Diane Lipscombe - Barrington RI
Stephanie Schorge - Smithfield RI
Assignee:
Brown University Research Founddation - Providence RI
International Classification:
C07K 1400
US Classification:
530350, 530300
Abstract:
The invention pertains to a human N-type calcium channel isoform, h , which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human h channel. Also included are human N-type calcium channel h subunit inhibitors which inhibit human N-type calcium channel h subunit activity by inhibiting the expression or function of human N-type calcium channel h subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e. g. , neuropathic pain, and traumatic brain injury.

Minimally-Invasive And Activity-Dependent Control Of Excitable Cells

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US Patent:
20180044397, Feb 15, 2018
Filed:
Jan 22, 2016
Appl. No.:
15/545428
Inventors:
- Providence RI, US
- Mount Pleasant MI, US
Diane LIPSCOMBE - Barrington RI, US
International Classification:
C07K 14/705
A61N 5/06
A01K 67/027
Abstract:
The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.
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Diane Lipscombe from Barrington, RI, age ~65 Get Report