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Dhanalakshmi Kasi

from Laurel, MD
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Also known as:
Dhana A Kasi, Akshmi Kasi Dhanal, Kasi Dhanalakshmi, Kasi Dhanalaks, Kasi Dhanalakshm
Phone and address:
8473 Charmed Days, Laurel, MD 20723
Connected to:
Anand N Kasi, 50Krishna Kasi, 69Ravikiran S Kasi, 52Bruce E Kasian, 65Christopher M Kasian, 43John Kasian, 59Katsiaryna Kasiankova, 40Katarzyna A Kasiarz, 39Louis Kasibante, 37Sreekant Kasibhatta, 58

Dhanalakshmi Kasi Phones & Addresses

  • 8473 Charmed Days, Laurel, MD 20723
  • Silver Spring, MD
  • Tustin, CA
  • Los Angeles, CA
  • Pittsburgh, PA
  • Buffalo, NY

Work

Company: Fda Mar 2014 Position: Chemist reviewer

Education

School / High School: Annamalai University, Annamalainagar

Skills

Medicinal Chemistry • Nmr • Chemistry • Organic Synthesis • Drug Discovery • Protein Chemistry • Hplc • Laboratory • Ir • Heterocyclic Chemistry • Oncology • Biochemistry • Formulation • Analytical Chemistry • Gc Ms • Asymmetric Synthesis • Combinatorial Chemistry • Spectroscopy • Uv • Natural Products Synthesis • Peptides Synthesis • Metal Catalysed Organic Reactions • Click Chemistry • Process Chemistry • Method Validation • Cmc • Structure Elucidation • Gpc • V&V

Languages

English • Tamil

Industries

Pharmaceuticals

Resumes

Resumes

Dhanalakshmi Kasi Photo 1

Chemist Reviewer

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Location:
Silver Spring, MD
Industry:
Pharmaceuticals
Work:
Fda
Chemist Reviewer
B. Braun Medical Dec 2013 - Mar 2014
Senior Chemistry Specialist
Siemens Healthcare Oct 2006 - Jan 2013
Senior Scientist
University of Pittsburgh 2005 - 2006
Post-Doc
University at Buffalo 2004 - 2005
Post-Doc
Education:
Annamalai University, Annamalainagar
Madras University
Master of Science, Masters, Organic Chemistry Indian Institute of Technology
Doctorates, Doctor of Philosophy, Philosophy, Organic Chemistry University of Madras
Bachelors, Bachelor of Science, Chemistry
Skills:
Medicinal Chemistry
Nmr
Chemistry
Organic Synthesis
Drug Discovery
Protein Chemistry
Hplc
Laboratory
Ir
Heterocyclic Chemistry
Oncology
Biochemistry
Formulation
Analytical Chemistry
Gc Ms
Asymmetric Synthesis
Combinatorial Chemistry
Spectroscopy
Uv
Natural Products Synthesis
Peptides Synthesis
Metal Catalysed Organic Reactions
Click Chemistry
Process Chemistry
Method Validation
Cmc
Structure Elucidation
Gpc
V&V
Languages:
English
Tamil

Publications

Us Patents

Development Of Molecular Imaging Probes For Carbonic Anhydrase-Ix Using Click Chemistry

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US Patent:
7829063, Nov 9, 2010
Filed:
Apr 7, 2008
Appl. No.:
12/099135
Inventors:
Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Los Angeles CA, US
Wei Zhang - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Canton MA, US
Peter J. H. Scott - Marina-del-Ray CA, US
Zhiyong Gao - Los Angeles CA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
A61K 51/00
C07D 343/00
US Classification:
424 111, 549 32
Abstract:
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

Nitro-Imidazole Hypoxia Imaging Agent

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US Patent:
7977361, Jul 12, 2011
Filed:
Jul 15, 2010
Appl. No.:
12/836926
Inventors:
Thomas Lee Collier - Perkasie PA, US
Brian A. Duclos - Kalamazoo MI, US
Umesh B. Gangadharmath - Los Angeles CA, US
Zhiyong Gao - Wynnewood PA, US
Farhad Karimi - Mansfield MA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Qianwa Liang - Hacienda Heights CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Tieming Zhao - Los Angeles CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
C07D 249/04
A61K 31/4192
US Classification:
514359, 514397, 548255
Abstract:
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.

Achievement Of A High Therapeutic Index Through Molecular Imaging Guided Targeted Drug Treatment

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US Patent:
8293206, Oct 23, 2012
Filed:
Jun 1, 2009
Appl. No.:
12/455346
Inventors:
Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Kai Chen - Rockville MD, US
Dhanalakshmi Kasi - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Gang Chen - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
A61M 36/14
A61K 39/00
US Classification:
424 169, 4241811
Abstract:
The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.

Imaging Agents For Detecting Neurological Dysfunction

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US Patent:
8318132, Nov 27, 2012
Filed:
Feb 17, 2009
Appl. No.:
12/372717
Inventors:
Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Peter J. H. Scott - Marina-del-Rey CA, US
Kai Chen - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Anjana Sinha - San Diego CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
A61K 51/00
A61M 36/14
US Classification:
424 111, 424 189, 424 185, 424 181, 424 165, 424 91
Abstract:
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

Development Of Molecular Imaging Probes For Carbonic Anhydrase-Ix Using Click Chemistry

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US Patent:
8354092, Jan 15, 2013
Filed:
Aug 25, 2010
Appl. No.:
12/862955
Inventors:
Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Rockville MD, US
Wei Zhang - Norwood MA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Mansfield MA, US
Peter J. H. Scott - Ypsilanti MI, US
Zhiyong Gao - Wynnewood PA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
A61K 51/00
C07D 249/00
C07D 343/00
US Classification:
424 153, 514359, 514449, 514461, 530330, 548255, 549429
Abstract:
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

Imaging Agents Useful For Identifying Ad Pathology

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US Patent:
8420052, Apr 16, 2013
Filed:
Jul 24, 2009
Appl. No.:
12/509259
Inventors:
Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Kai Chen - Rockville MD, US
Anjana Sinha - San Diego CA, US
Eric Wang - San Diego CA, US
Gang Chen - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Henry Clifton Padgett - Hermosa Beach CA, US
Qianwa Liang - Hacienda Heights CA, US
Zhiyong Gao - Wynnewood PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
A61K 51/00
A61M 36/14
US Classification:
424 189, 424 111, 424 165, 424 181, 424 185
Abstract:
Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.

Cyclic Azapeptides As Integrin Markers And Methods Of Using

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US Patent:
8486372, Jul 16, 2013
Filed:
May 23, 2011
Appl. No.:
13/113580
Inventors:
Hartmuth C. Kolb - Playa Del Rey CA, US
Kai Chen - San Gabriel CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Gang Chen - Redondo Beach CA, US
Qianwa Liang - Hacienda Heights CA, US
Tieming Zhao - Los Angeles CA, US
Assignee:
Siemens Medical Solutions USA, Inc. - Malvern PA
International Classification:
A61B 5/055
US Classification:
424 93, 424 111, 424 165, 424 169, 424 181, 424 185, 424 189, 424 91, 424 92, 514 11
Abstract:
The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

Imaging Agents For Detecting Neurological Disorders

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US Patent:
8491869, Jul 23, 2013
Filed:
Mar 23, 2010
Appl. No.:
12/661777
Inventors:
Umesh B. Gangadharmath - Los Angeles CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Peter J. H. Scott - Ypsilanti MI, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Anna Katrin Szardenings - Torrance CA, US
Anjana Sinha - San Diego CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Chul Yu - Los Angeles CA, US
Changhui Liu - Los Angeles CA, US
Daniel Kurt Cashion - Manhattan Beach CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 51/00
A61M 36/14
US Classification:
424 189, 424 111, 424 165, 424 181, 424 185
Abstract:
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
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Dhanalakshmi Kasi from Laurel, MD Get Report