Desong Zhong

20040171834, Sep 2, 2004

Aug 21, 2003

10/646284

Anita Lewin - Chapel Hill NC, US
James Hayes - Durham NC, US
Desong Zhong - Cary NC, US

C07D451/04

546/129000

This invention provides a method for preparing a hydroxyalkyl tropane ester, comprising: (a) contacting a tropane and 1,1′-carbonyldiimidazole to produce an activated tropane ester; (b) contacting the activated tropane ester with an excess of an alkanediol to form a reaction mixture; and (c) maintaining the reaction mixture at a temperature and for a sufficient time for the activated tropane ester to react with the alkanediol to form the corresponding hydroxyalkyl tropane ester. This method may be used to produce hydroxyalkyl derivatives of tropanes such as benzoylecgonine, ecgonine and ecgonidine.

6416735, Jul 9, 2002

Nov 8, 1999

09/435614

Frank Ivy Carroll - Durham NC
Philip Abraham - Cary NC
Desong Zhong - Apex NC

Research Triangle Institute - Research Triangle Park NC

A61K 5100

424 181, 424 185, 424 189

Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimers and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.