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Desong Zhong Phones & Addresses

  • Burlington, IA
  • Apex, NC
  • 107 Carswell Ln, Cary, NC 27511 (919) 303-3678
  • 302 Bargate Dr, Cary, NC 27511 (919) 460-9134

Publications

Us Patents

Methods For Producing Hydroxyalkyl Tropane Esters

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US Patent:
20040171834, Sep 2, 2004
Filed:
Aug 21, 2003
Appl. No.:
10/646284
Inventors:
Anita Lewin - Chapel Hill NC, US
James Hayes - Durham NC, US
Desong Zhong - Cary NC, US
International Classification:
C07D451/04
US Classification:
546/129000
Abstract:
This invention provides a method for preparing a hydroxyalkyl tropane ester, comprising: (a) contacting a tropane and 1,1′-carbonyldiimidazole to produce an activated tropane ester; (b) contacting the activated tropane ester with an excess of an alkanediol to form a reaction mixture; and (c) maintaining the reaction mixture at a temperature and for a sufficient time for the activated tropane ester to react with the alkanediol to form the corresponding hydroxyalkyl tropane ester. This method may be used to produce hydroxyalkyl derivatives of tropanes such as benzoylecgonine, ecgonine and ecgonidine.

Ligands For -7 Nicotinic Acetylcholine Receptors Based On Methyllcaconitine

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US Patent:
6416735, Jul 9, 2002
Filed:
Nov 8, 1999
Appl. No.:
09/435614
Inventors:
Frank Ivy Carroll - Durham NC
Philip Abraham - Cary NC
Desong Zhong - Apex NC
Assignee:
Research Triangle Institute - Research Triangle Park NC
International Classification:
A61K 5100
US Classification:
424 181, 424 185, 424 189
Abstract:
Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimers and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.
Desong Zhong from Burlington, IA, age ~63 Get Report