US Patent:
20040138230, Jul 15, 2004
Inventors:
Tonja Andreana - Somerville MA, US
Stephen Yong Cho - Saline MI, US
James Graham - Ann Arbor MI, US
Tracy Gregory - Parma MI, US
Harry Howard - Bristol CT, US
Brian Kornberg - Ann Arbor MI, US
Sham Nikam - Ann Arbor MI, US
Derek Pflum - Northville MI, US
International Classification:
A61K031/496
C 07D 4 3/14
US Classification:
514/253070, 544/363000, 514/314000, 546/157000
Abstract:
This invention relates to compounds of the formula 1 wherein X, Y, Z, A, R, R, R, R, R, Wand Ware defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.