Resumes
Resumes
Dennis Stelzner Phones & Addresses
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3879 El Poinier Ct, Sarasota, FL 34232
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309 Stonecrest Dr, Syracuse, NY 13214 (315) 446-6037
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31 Nursery Ln, Syracuse, NY 13210 (315) 423-5547
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Fiesta Key, FL
Publications
Us Patents
Chondroitinase Treatment Method For Demyelination-Related Conditions And Diseases
View pageUS Patent:
20110142949, Jun 16, 2011
Filed:
Oct 18, 2010
Appl. No.:
12/906399
Inventors:
Donna J. Osterhout - East Syracuse NY, US
Dennis Stelzner - Syracuse NY, US
Dennis Stelzner - Syracuse NY, US
Assignee:
The Research Foundation of State University of New York - Albany NY
International Classification:
A61K 38/43
A61K 9/14
A61P 25/00
A61K 9/14
A61P 25/00
US Classification:
424497, 424 941, 424490
Abstract:
A method of treating a mammal suffering from a demyelinating disease or condition, the method comprising administering chondroitinase to said mammal at a site where demyelination has occurred.
Nanosphere/Microsphere Delivery System For The Treatment Of Spinal Cord Injury
View pageUS Patent:
20110212136, Sep 1, 2011
Filed:
Sep 27, 2010
Appl. No.:
12/891303
Inventors:
Donna J. Osterhout - East Syracuse NY, US
Julie M. Hasenwinkel - Manlius NY, US
Dennis J. Stelzner - Syracuse NY, US
Julie M. Hasenwinkel - Manlius NY, US
Dennis J. Stelzner - Syracuse NY, US
Assignee:
The Research Foundation of State University of New York - Albany NY
Syracuse University - Syracuse NY
Syracuse University - Syracuse NY
International Classification:
A61K 38/20
A61K 9/00
A61K 38/43
A61K 39/395
A61K 38/21
A61P 25/00
A61P 17/02
A61K 9/00
A61K 38/43
A61K 39/395
A61K 38/21
A61P 25/00
A61P 17/02
US Classification:
424400, 424 941, 4241301, 424 852, 424 857, 424 856, 4241721
Abstract:
A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided.
Nanosphere/Microsphere Delivery System For The Treatment Of Spinal Cord Injury
View pageUS Patent:
20070116697, May 24, 2007
Filed:
Jun 14, 2006
Appl. No.:
11/452721
Inventors:
Donna Osterhout - East Syracuse NY, US
Julie Hasenwinkel - Manlius NY, US
Dennis Stelzner - Syracuse NY, US
Julie Hasenwinkel - Manlius NY, US
Dennis Stelzner - Syracuse NY, US
Assignee:
The Research Foundation of State of University of New York - Albany NY
International Classification:
A61K 38/47
A61K 9/14
A61K 9/14
US Classification:
424094610, 424489000, 977906000
Abstract:
A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided.