Dennis Lawrence Nosco

6428768, Aug 6, 2002

May 15, 1995

08/442252

Mark A. DeRosch - St. Louis MO
Edward A. Deutsch - Maryland Heights MO
Mary Marmion Dyszlewski - Maryland Heights MO
Dennis L. Nosco - Florissant MO

MallincKrodt Medical, Inc.

A61K 5100

424 165, 534 10, 534 14

The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.

53649532, Nov 15, 1994

Nov 5, 1992

7/971789

Julie A. Beaty - Florissant MO
Edward A. Deutsch - Maryland Heights MO
Dennis L. Nosco - Florissant MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61K 4900
C07F 1100
C07F 1300
C07F 1500

556 46

The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to paramagnetic metal clusters having oxygen and/or nitrogen containing ligands useful as contrast agents for magnetic resonance imaging (MRI).

54199050, May 30, 1995

Mar 23, 1992

7/855256

Dennis L. Nosco - Florissant MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61K 4902

424 165

The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to a radiopharmaceutical compositions comprising the complexes, to the use of the compositions for examining the renal function, and to a kit for preparing such compositions.

54684650, Nov 21, 1995

Jul 6, 1994

8/271921

Edward A. Deutsch - Maryland Heights MO
Karen F. Deutsch - Maryland Heights MO
William P. Cacheris - Florissant MO
William H. Ralston - St. Charles MO
David H. White - Ballwin MO
Dennis L. Nosco - Florissant MO
Robert G. Wolfangel - Ballwin MO
Janet B. Wilking - Ferguson MO
Linda Meeh - St. Louis MO
Steven R. Woulfe - Ballwin MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61K 4904

424 94

Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for. sup. 19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.

53002806, Apr 5, 1994

Feb 14, 1992

7/836644

Mark A. DeRosch - St. Louis MO
Edward A. Deutsch - Maryland Heights MO
Mary M. Dyszlewski - Maryland Heights MO
Dennis L. Nosco - Florissant MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61K 4300
A61K 4902
A61K 31715

424 153

The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.

53208242, Jun 14, 1994

Apr 16, 1993

8/047322

James W. Brodack - Florissant MO
Edward A. Deutsch - Maryland Heights MO
Karen F. Deutsch - Maryland Heights MO
Dennis L. Nosco - Florissant MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61K 4300
A61N 510

424 137

The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a substantially insoluble particle as the radiolabelled synovectomy agent in a sufficient amount of provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.

54076595, Apr 18, 1995

Apr 13, 1993

8/047129

Edward A. Deutsch - Maryland Heights MO
Karen F. Deutsch - Maryland Heights MO
Dennis L. Nosco - Florissant MO
William H. Ralston - St. Charles MO
David H. White - Ballwin MO
Janet B. Wilking - Ferguson MO
Robert G. Wolfangel - Ballwin MO
Steven R. Woulfe - Ballwin MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61B 5055

424 9

Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.

51165988, May 26, 1992

Oct 29, 1990

7/605207

Dennis L. Nosco - Florissant MO

Mallinckrodt Medical, Inc. - St. Louis MO

A61K 4902
C07F 1300

424 11

The present invention relates to novel technetium-99 m complexes and to methods of preparing the complexes. The present invention further relates to a radiopharmaceutical compositions comprising the complexes, to the use of the compositions for examining the renal function, and to a kit for preparing such compositions.