Inventors:
Dennis J. Kopecko - Silver Spring MD, US
DeQi Xu - Columbia MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 39/112
A61K 39/02
C07H 21/04
US Classification:
4242581, 424 931, 424 932, 4241841, 4242001, 4242031, 4242341, 536 231, 536 237
Abstract:
The invention relates to Ty21a comprising core-linked serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.