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Dena C Marrinucci

from San Diego, CA
Age ~43
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Related to:
Bianca Marrinucci, 30Sandra MarrinucciDominic P Marrinucci, 68
Connected to:
Ruth M Marrion, 67Adrian Marriott, 47Adrienne M Marriott, 44Alicia A Marriott, 56Alisha R Marriott, 55Anita G Marriott, 61Ann M Marriott, 86April R Marriott, 47Betty J Marriott, 41Bob L Marriott, 87

Dena Marrinucci Phones & Addresses

  • 3759 Carmel View Rd #2, San Diego, CA 92130
  • North Port, FL
  • Bedford, NH
  • Del Mar, CA
  • 348 Rios Ave, Solana Beach, CA 92075
  • La Jolla, CA

Work

Company: Connect - san diego Oct 2019 Position: Board member, executive committee

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Scripps Research Specialities: Biology

Skills

Companion Diagnostics • Personalized Medicine • Clinical Operations • Clinical Trials • Oncology • Molecular Diagnostics • Biotechnology • Glp • Cell • Cancer Research • Cancer • Clinical Research • Start Ups • Assay Development • Medical Devices • Biopharmaceuticals • Diagnostics • Validation • Laboratory • Immunofluorescence • Fluorescence Microscopy • Business Development • Six Sigma • Life Sciences • Research and Development • In Vitro Diagnostics • Executive Leadership • Business Strategy • Operational Excellence • Program Management • Product Development

Industries

Biotechnology

Resumes

Resumes

Dena Marrinucci Photo 1

Chief Operating Officer

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Location:
San Diego, CA
Industry:
Biotechnology
Work:
Connect - San Diego
Board Member, Executive Committee
Lynx Biosciences, Inc.
Advisor
Epic Sciences Jan 2014 - Jan 2016
Chief Scientific Officer
Epic Sciences Oct 2010 - Jan 2014
Senior Director, Companion Diagnostic Parterships and Laboratory Operations
The Scripps Research Institute Aug 2009 - Oct 2010
Project Manager For 4Db Physical Sciences Oncology Center
Education:
Scripps Research
Doctorates, Doctor of Philosophy, Biology University of Vermont
Bachelors, Bachelor of Science, Chemistry
Skills:
Companion Diagnostics
Personalized Medicine
Clinical Operations
Clinical Trials
Oncology
Molecular Diagnostics
Biotechnology
Glp
Cell
Cancer Research
Cancer
Clinical Research
Start Ups
Assay Development
Medical Devices
Biopharmaceuticals
Diagnostics
Validation
Laboratory
Immunofluorescence
Fluorescence Microscopy
Business Development
Six Sigma
Life Sciences
Research and Development
In Vitro Diagnostics
Executive Leadership
Business Strategy
Operational Excellence
Program Management
Product Development

Publications

Us Patents

Methods For Detection Of Circulating Tumor Cells And Methods Of Diagnosis Of Cancer In Mammalian Subject

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US Patent:
20090317836, Dec 24, 2009
Filed:
Jan 30, 2007
Appl. No.:
12/223351
Inventors:
Peter Kuhn - Solana Beach CA, US
Dena Marrinucci - Solana Beach CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
G01N 33/574
US Classification:
435 723
Abstract:
Methods are provided for detecting circulating tumor cells in a mammalian subject. Methods of diagnosing cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of metastatic cancer or early stage cancer.

Methods For The Detection Of Circulating Tumor Cells

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US Patent:
20100247492, Sep 30, 2010
Filed:
Sep 3, 2009
Appl. No.:
12/553733
Inventors:
Peter Kuhn - Solana Beach CA, US
John H. Griffin - Del Mar CA, US
Kelly Bethel - San Diego CA, US
Dena Marrinucci - Del Mar CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
A61K 35/12
C12Q 1/02
C12Q 1/68
G01N 33/53
A61P 35/00
US Classification:
424 937, 435 29, 435 6, 435 723
Abstract:
The present invention provides methods for revealing, detecting, and analyzing circulating tumor cells in the blood of a subject. Revealing detectable circulating tumor cells allows for early stage detection and diagnosis in addition to long term prognosis in subjects with cancer. Additionally, enrichment allows for robust detection and clinically meaningful analysis of low volume samples for use in clinical settings as well as innovative methods for the treatment of cancers.

Method Of Using Non-Rare Cells To Detect Rare Cells

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US Patent:
20120276555, Nov 1, 2012
Filed:
Oct 20, 2010
Appl. No.:
13/503014
Inventors:
Peter Kuhn - Solana Beach CA, US
Anand Kolatkar - San Diego CA, US
Joshua Kunken - San Diego CA, US
Dena Marrinucci - Del Mar CA, US
Xing Yang - San Diego CA, US
John R. Stuelpnagel - Santa Barbara CA, US
International Classification:
G01N 21/64
US Classification:
435 723
Abstract:
The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. Additionally, the invention utilizes both one and multi-dimensional parameterized data in a decision making process.

Methods For The Detection Of Circulating Tumor Cells

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US Patent:
20130252259, Sep 26, 2013
Filed:
May 17, 2013
Appl. No.:
13/897136
Inventors:
John Griffin - Del Mar CA, US
Kelly Bethel - San Diego CA, US
Dena Marrinucci - Del Mar CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
G01N 33/574
US Classification:
435 723, 435 71
Abstract:
The present invention provides methods for revealing, detecting, and analyzing circulating tumor cells in the blood of a subject. Revealing detectable circulating tumor cells allows for early stage detection and diagnosis in addition to long term prognosis in subjects with cancer. Additionally, enrichment allows for robust detection and clinically meaningful analysis of low volume samples for use in clinical settings as well as innovative methods for the treatment of cancers.

Single Cell Genomic Profiling Of Circulating Tumor Cells (Ctcs) In Metastatic Disease To Characterize Disease Heterogeneity

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US Patent:
20220390451, Dec 8, 2022
Filed:
Jan 19, 2022
Appl. No.:
17/579437
Inventors:
- San Diego CA, US
Dena Marrinucci - San Diego CA, US
International Classification:
G01N 33/574
G01N 21/00
G01N 15/00
G01N 33/50
C12Q 1/6886
G01N 15/14
G01N 33/52
Abstract:
The disclosure provides a method of detecting heterogeneity of disease in a cancer patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) isolating the CTCs from the sample; (c) individually characterizing genomic parameters to generate a genomic profile for each of the CTCs, and (d) determining heterogeneity of disease in the cancer patient based on the profile. In some embodiments, the cancer is prostate cancer. In some embodiments, the prostate cancer is hormone refractory.

Methods And Compositions For Reversing Platelet Clumping

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US Patent:
20220214253, Jul 7, 2022
Filed:
May 8, 2020
Appl. No.:
17/608458
Inventors:
- San Diego CA, US
Renee L. Higgins - Santee CA, US
Jeffrey A. Hawkins - San Marcos CA, US
Dena C. Marrinucci - San Diego CA, US
International Classification:
G01N 1/38
G01N 1/28
G01N 33/86
Abstract:
Provided herein are methods and related compositions and kits for dissolution of platelet clumps formed in collected blood samples. The present methods, compositions and kits are useful for improving blood sample quality and blood assay accuracy in a lab setting, especially in preventing misdiagnosis such as pseudothrombocytopenia or pseudoleukocytosis.

Method Of Using Non-Rare Cells To Detect Rare Cells

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US Patent:
20230085158, Mar 16, 2023
Filed:
May 17, 2022
Appl. No.:
17/746756
Inventors:
- La Jolla CA, US
- San Diego CA, US
Joshua Kunken - San Diego CA, US
Dena Marrinucci - San Diego CA, US
Xing Yang - San Diego CA, US
John R. Stuelpnagel - Santa Barbara CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
Epic Sciences, Inc. - San Diego CA
International Classification:
G01N 33/574
G01N 33/50
G01N 33/68
Abstract:
The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. Additionally, the invention utilizes both one and multi-dimensional parameterized data in a decision making process.

Single Cell Genomic Profiling Of Circulating Tumor Cells (Ctcs) In Metastatic Disease To Characterize Disease Heterogeneity

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US Patent:
20210405055, Dec 30, 2021
Filed:
Jan 6, 2021
Appl. No.:
17/142767
Inventors:
- San Diego CA, US
Dena Marrinucci - San Diego CA, US
International Classification:
G01N 33/574
C12Q 1/68
C12Q 1/6806
C12Q 1/6841
Abstract:
The disclosure provides a method of detecting heterogeneity of disease in a cancer patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) isolating the CTCs from the sample; (c) individually characterizing genomic parameters to generate a genomic profile for each of the CTCs, and (c) determining heterogeneity of disease in the cancer patient based on the profile. In some embodiments, the cancer is prostate cancer. In some embodiments, the prostate cancer is hormone refractory.
Control profile
Dena C Marrinucci from San Diego, CA, age ~43 Get Report