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Demetri T Moustakas

from Belmont, MA
Age ~48
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Also known as:
Demetri Theodore Moustakas, Demetri Theordore Moustakas, Demitri Moustakas
Phone and address:
367 Pleasant St, Belmont, MA 02478
(617) 484-0821
Related to:
Lizbeth D Scordo, 49
Connected to:
Anna Moustakas, 69Apostolos Moustakas, 76Dimitrios N Moustakas, 44Eleni M Moustakas, 40Elias Moustakas, 66Emmanuel I Moustakakis, 91Jennifer C Moustakas, 49Luke M Moustakas, 54Nick D Moustakas, 77Eunice Moustaoui, 57

Demetri Moustakas Phones & Addresses

  • 367 Pleasant St, Belmont, MA 02478 (617) 484-0821
  • 7 Wright Ave, Medford, MA 02155
  • 1001 Shoreline Dr, Alameda, CA 94501 (510) 748-0750
  • 1801 Shoreline Dr, Alameda, CA 94501 (510) 748-0750
  • Berkeley, CA
  • 26 Rocky Brook Rd, Dover, MA 02030 (508) 785-1949
  • Boston, MA
  • 26 Rocky Brook Rd, Dover, MA 02030

Work

Position: Production Occupations

Education

Degree: Associate degree or higher

Resumes

Resumes

Demetri Moustakas Photo 1

Principal Scientist

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Location:
367 Pleasant St, Belmont, MA 02478
Industry:
Biotechnology
Work:
Alkermes Sep 2012 - Jun 2017
Staff Scientist
Relay Therapeutics, Inc. Sep 2012 - Jun 2017
Principal Scientist
Astrazeneca Nov 2008 - Sep 2012
Senior Scientist
Harvard University Sep 2004 - Nov 2008
Postdoctoral Fellow
Pfizer 2007 - 2008
Consultant
Education:
University of California, Berkeley 1998 - 2004
Doctorates, Doctor of Philosophy, Bioengineering University of California, San Francisco 1998 - 2004
Doctorates, Doctor of Philosophy, Bioengineering, Chemistry Boston University 1994 - 1998
Bachelors, Bachelor of Science, Biomedical Engineering
Skills:
Drug Design
Computational Chemistry
Chemistry
Drug Discovery
Protein Chemistry
Biophysics
Computational Biology
Systems Biology
Medicinal Chemistry
Virtual Screening
Biochemistry
Cell
X Ray Crystallography
Structural Biology
Cheminformatics
Docking
Demetri Moustakas Photo 2

Demetri Moustakas

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Publications

Us Patents

Stabilizing Proteins Against Denaturation And Inactivation By Charged Detergents Using Chemical Modifications, Including Modifications That Increase Net Charge

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US Patent:
20080113421, May 15, 2008
Filed:
Dec 11, 2006
Appl. No.:
11/637203
Inventors:
Bryan F. Shaw - Somerville MA, US
Katherine L. Gudiksen - San Francisco CA, US
Irina Gitlin - Brookline MA, US
Demetri T. Moustakas - Medford MA, US
George M. Whitesides - Newton MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 9/96
US Classification:
435188
Abstract:
The present invention generally relates to enzymes and other proteins resistant to denaturation, and techniques for making and using the same. In one aspect, lysine and/or other charged residues within an enzyme are reacted in some fashion, which can render the enzyme more resistant to denaturation. For example, the lysine residue may be neutralized by acetylating the residue, for instance, by exposure to acetic anhydride. In some aspects, the enzyme, after reaction, may be relatively resistant to degradation when placed in a harsh environment, for example, when exposed to sodium dodecyl sulfate at a concentration of at least about 2.5 mM in Tris-Gly buffer. The enzyme may still be susceptible to denaturation in some cases, but at a much slower rate (e.g., the denaturation time constant may be higher). Other aspects of the invention are directed to enzymes prepared in such fashion, methods of promoting or using such enzymes, kits involving such enzymes, and the like.

Fgfr Inhibitors And Methods Of Use Thereof

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US Patent:
20230104574, Apr 6, 2023
Filed:
May 12, 2020
Appl. No.:
17/595257
Inventors:
- Cambridge MA, US
- New York NY, US
Alexander M. TAYLOR - Cambridge MA, US
Fabrizio GIORDANETTO - New York NY, US
Demetri T. MOUSTAKAS - Cambridge MA, US
Thomas H. MCLEAN - Cambridge MA, US
Brandi M. HUDSON - Cambridge MA, US
Mary M. MADER - Cambridge MA, US
Pelin AYAZ - New York NY, US
Dina A. SHARON - New York NY, US
Ravi KURUKULASURIYA - Cambridge MA, US
Alessandro BOEZIO - Cambridge MA, US
International Classification:
C07D 487/04
C07D 519/00
C07D 491/048
C07D 498/22
C07D 498/02
C07D 487/22
Abstract:
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with FGFR signaling with the compounds and compositions of the disclosure.

Novel Thiophene Compounds For Long-Acting Injectable Compositions And Related Methods

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US Patent:
20200325157, Oct 15, 2020
Filed:
Nov 5, 2019
Appl. No.:
16/674040
Inventors:
- Dublin, IE
Hoan Huynh - Waltham MA, US
Lewis D. Pennington - Arlington MA, US
Ingo Mugge - Waltham MA, US
Baudouin Gerard - Arlington MA, US
Markus Haeberlein - Wellesley MA, US
Roman A. Valiulin - Cambridge MA, US
Julius F. Remenar - Framingham MA, US
Demetri Theodore Moustakas - Belmont MA, US
Thomas Andrew Wynn - Lexington MA, US
Todd Bosanac - New Milford CT, US
International Classification:
C07D 519/00
A61K 31/485
Abstract:
The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Compounds For The Treatment Of Pain

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US Patent:
20200255383, Aug 13, 2020
Filed:
Feb 13, 2020
Appl. No.:
16/790224
Inventors:
- Waltham MA, US
Juan C. Alvarez - Lincoln MA, US
Demetri Theodore Moustakas - Belmont MA, US
Markus Haeberlein - Wellesley MA, US
Lewis D. Pennington - Arlington MA, US
International Classification:
C07D 221/26
A61K 31/439
C07D 453/02
A61P 29/00
C07D 409/04
C07D 405/04
C07D 401/14
C07D 401/04
A61P 25/04
Abstract:
Provided herein are compounds that are useful in the treatment of pain in a subject.

Novel Naphthylenyl Compounds For Long-Acting Injectable Compositions And Related Methods

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US Patent:
20200016151, Jan 16, 2020
Filed:
Jul 11, 2019
Appl. No.:
16/508703
Inventors:
- Dublin, IE
Hoan Huynh - Waltham MA, US
Lewis D. Pennington - Arlington MA, US
Ingo Mugge - Waltham MA, US
Baudouin Gerard - Arlington MA, US
Markus Haeberlein - Wellesley MA, US
Roman A. Valiulin - Cambridge MA, US
Julius F. Remenar - Framingham MA, US
Demetri T. Moustakas - Belmont MA, US
Thomas Andrew Wynn - Lexington MA, US
Todd Bosanac - New Milford CT, US
International Classification:
A61K 31/485
A61K 9/00
A61K 47/55
A61K 47/54
Abstract:
The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Novel Thienothiophene Compounds For Long-Acting Injectable Compositions And Related Methods

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US Patent:
20200017529, Jan 16, 2020
Filed:
Jul 11, 2019
Appl. No.:
16/508697
Inventors:
- Dublin, IE
Hoan Huynh - Waltham MA, US
Lewis D. Pennington - Arlington MA, US
Ingo Mugge - Waltham MA, US
Baudouin Gerard - Arlington MA, US
Markus Haeberlein - Wellesley MA, US
Roman A. Valiulin - Cambridge MA, US
Julius F. Remenar - Framingham MA, US
Demetri T. Moustakas - Belmont MA, US
Thomas Andrew Wynn - Lexington MA, US
Todd Bosanac - New Milford CT, US
International Classification:
C07D 519/00
A61K 9/00
Abstract:
The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Compounds For The Treatment Of Pain

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US Patent:
20190241524, Aug 8, 2019
Filed:
Feb 4, 2019
Appl. No.:
16/267025
Inventors:
- Waltham MA, US
Juan C. Alvarez - Lincoln MA, US
Demetri Theodore Moustakas - Belmont MA, US
Markus Haeberlein - Wellesley MA, US
Lewis D. Pennington - Arlington MA, US
International Classification:
C07D 221/26
A61P 25/04
C07D 401/04
C07D 401/14
C07D 409/04
C07D 405/04
Abstract:
Provided herein are compounds that are useful in the treatment of pain in a subject.

Single Chain Fc Fusion Proteins

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US Patent:
20180289825, Oct 11, 2018
Filed:
Apr 10, 2018
Appl. No.:
15/949596
Inventors:
- Waltham MA, US
Demetri T. Moustakas - Belmont MA, US
Heather R. Brodkin - Warwick RI, US
Leslie A. McSweeney - Milford MA, US
International Classification:
A61K 47/64
C12N 9/64
A61K 38/17
A61K 38/20
C07K 14/715
C07K 14/705
C07K 14/565
C07K 14/55
C07K 14/54
A61K 38/48
A61K 38/21
A61K 38/00
Abstract:
The present invention provides novel, single chain Fc fusion proteins having improved properties. The invention provides single chain fusions of soluble proteins fused to the Fc region of an immunoglobulin via a novel linker comprising a constant region of an immunoglobulin light chain linked to a CH1 constant region of an immunoglobulin heavy chain. This novel linker confers favorable properties on the Fc fusion proteins of the invention such as improved bioactivity and increased half-life as compared to non-Fc fusion counterparts or as compared to prior art Fc fusion proteins. The novel Fc fusion protein scaffold as described herein may be designed to include soluble proteins of interest capable of binding or interacting with any target of interest. Preferably, the Fc fusion protein of the invention is a dimer. The dimer preferably forms via a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins of the invention.
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Demetri T Moustakas from Belmont, MA, age ~48 Get Report