US Patent:
20110092428, Apr 21, 2011
Inventors:
Deborah J. Stumpo - Durham NC, US
Perry J. Blackshear - Chapel Hill NC, US
Assignee:
The United States of America,as represented by the Secretary ,Department of Healthyand Human Service - Beathesda MD
International Classification:
A61K 38/16
C12Q 1/68
A61P 35/00
A61P 35/02
A61P 7/00
US Classification:
514 135, 435 6, 514 193, 514 196
Abstract:
A method of detecting abnormal hematopoiesis in a subject based on abnormal expression of ZFP36L2, a method of controlling hematopoiesis in a subject altering the level or activity of ZFP36L2 protein in the subject, a method of screening for compounds that modulate hematopoiesis based on changes to ZFP36L2 expression, and compounds identified thereby.