Inventors:
Mary J. Bossard - Madison AL, US
Steven O. Roczniak - Greensboro NC, US
Harold Zappe - Harvest AL, US
Yujun Wang - Madison AL, US
Ping Zhang - Madison AL, US
Dawei Sheng - Madison AL, US
C. Simone Jude-Fishburn - Redwood City CA, US
Elizabeth Louise Minamitani - Lacey's Spring AL, US
Xiaofeng Liu - Union City CA, US
Haim Moskowitz - San Diego CA, US
Dennis G. Fry - Huntsville AL, US
Cherie F. Ali - Burlingame CA, US
Christine Taylor Brew - Pacifica CA, US
Assignee:
Nektar Therapeutics - San Francisco CA
International Classification:
A61K 38/28
A61K 38/16
A61K 38/08
A61K 38/06
A61K 38/07
A61K 38/10
C07K 5/08
C07K 7/06
C07K 7/08
C07K 14/00
A61P 3/10
US Classification:
514 59, 514 213, 514 212, 514 217, 514 216, 514 219, 514 218, 514 215, 530303, 530331, 530330, 530329, 530328, 530327, 530326, 530324, 530350
Abstract:
The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.