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Darren L Whitehouse

from Westbrook, CT
Age ~56
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Also known as:
Darren Lee Whitehouse, Darren L Whithouse
Phone and address:
40 Fishing Brook Rd, Westbrook, CT 06498
(860) 399-3455
Related to:
Richard Wes Pack, 60Curtis B Pack, 46
Connected to:
Abigail E Whitehorn, 44Alexis C Whitehorn, 28Alfred L Whitehouse, 85Annette W Whitehorne, 71Benjamin Whitehouse, 84Cassandra Whitehouse, 92Christine M Whitehouse, 45David L Whitehorne, 55Denise L Whitehouse, 66Diane B Whitehouse, 75

Darren Whitehouse Phones & Addresses

  • 40 Fishing Brook Rd, Westbrook, CT 06498 (860) 399-3455
  • Essex, CT
  • Groton, CT
  • Decatur, GA
  • 40 Fishing Brook Rd, Westbrook, CT 06498

Work

Company: The institutes for pharmaceutical discovery (ipd), llc 2005 Position: Principal staff scientist

Education

School / High School: Yale University- New Haven, CT 1996 Specialities: Post-Doctoral Research in Organic Synthesis

Emails

d***[email protected]

Resumes

Resumes

Darren Whitehouse Photo 1

Darren Whitehouse

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Location:
23 Business Park Dr, Branford, CT 06405
Industry:
Pharmaceuticals
Work:
New England Discovery Partners (Nedp) Sep 2012 - Mar 2020
Principal Scientist and Co-Founder at New England Discovery Partners, Llc
Institute For Pharmaceutical Discovery 2006 - 2012
Staff Scientist
Neurogen Corporation 2005 - 2006
Research Fellow Ii
Institute For Pharmaceutical Discovery 1999 - 2005
Senior Research Scientist
Bristol-Myers Squibb 1997 - 1999
Research Investigator
Education:
Yale University 1996 - 1997
Emory University 1995 - 1996
Rwth Aachen University 1993 - 1995
The University of Manchester 1991 - 1993
Doctorates, Doctor of Philosophy The University of Manchester 1989 - 1991
Master of Science, Masters The University of Manchester 1986 - 1989
Bachelors, Bachelor of Science, Chemistry
Skills:
Drug Discovery
Medicinal Chemistry
Drug Design
Biotechnology
Heterocyclic Chemistry
Parallel Synthesis
Lead Change
Organic Chemistry
Lc Ms
Pharmaceutical Industry
Organic Synthesis
Purification
Combinatorial Chemistry
Chromatography
Hplc
Adme
Assay Development
Chemistry
Biomarkers
Life Sciences
Drug Metabolism
Drug Development
Pharmacokinetics
Nmr Spectroscopy
Dmpk
Mass Spectrometry
In Vitro
Gpcrs
Pharmaceutical Research
Lifesciences
Scifinder
Bioanalysis
Analytical Chemistry
Pharmacology
Peptide Synthesis
In Vivo
Ind
Uv/Vis
Languages:
English
German
Darren Whitehouse Photo 2

Darren Whitehouse

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Darren Whitehouse Photo 3

Darren Whitehouse Westbrook, CT

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Work:
The Institutes for Pharmaceutical Discovery (IPD), LLC

2005 to 2012
Principal Staff Scientist
Neurogen Corporation

2004 to 2005
Research Fellow II
The Institutes for Pharmaceutical Discovery, LLC

1999 to 2004
Sr. Research Scientist
Bristol-Myers Squibb Pharmaceutical Research Institute

1997 to 1999
Sr. Research Investigator, Combinatorial Drug Discovery (CDD)
Education:
Yale University
New Haven, CT
1996 to 1997
Post-Doctoral Research in Organic Synthesis
Emory University
Atlanta, GA
1996 to 1996
Post-Doctoral Research in Organic Synthesis
Institut fur Organische Chemie der RWTH
Aachen
1993 to 1995
Post-Doctoral Research in Organic Synthesis
University of Manchester
Manchester
Ph.D. in Synthetic Organic Chemistry
University of Manchester
Manchester
M.Sc. in Synthetic Organic Chemistry
University of Manchester
Manchester
B.Sc. in Chemistry

Publications

Us Patents

Heterocycle Substituted Carboxylic Acids

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US Patent:
7329680, Feb 12, 2008
Filed:
Apr 30, 2004
Appl. No.:
10/835818
Inventors:
Darren Whitehouse - Westbrook CT, US
Shaojing Hu - Hamden CT, US
Haiquan Fang - Madison CT, US
Kerry Combs - Wallingford CT, US
Michael C. Van Zandt - Guilford CT, US
Assignee:
The Institute for Pharmaceutical Discovery, LLC - Branford CT
International Classification:
C07D 277/38
A61K 31/425
US Classification:
514370, 548195
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I):Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Substituted Amino Carboxylic Acids

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US Patent:
7358248, Apr 15, 2008
Filed:
Apr 30, 2004
Appl. No.:
10/835817
Inventors:
Darren Whitehouse - Westbrook CT, US
Shaojing Hu - Hamden CT, US
Michael C. Van Zandt - Guilford CT, US
Garrett Parker - Branford CT, US
Thomas G. Meskill - New Haven CT, US
Assignee:
The Institute for Pharmaceutical Discovery LLC - Branford CT
International Classification:
A61K 31/5355
C07D 265/30
C07D 295/02
C07D 307/79
C07D 323/02
US Classification:
5142328, 514365, 514394, 514406, 544107, 5483051, 5483644, 549 43, 549434, 549469
Abstract:
Disclosed are compounds and pharmaceutically acceptable salts of formula (I):Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Substituted Carboxylic Acids

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US Patent:
7358364, Apr 15, 2008
Filed:
Apr 14, 2004
Appl. No.:
10/823842
Inventors:
Michael C. Van Zandt - Guilford CT, US
Darren Whitehouse - Westbrook CT, US
Kerry Combs - Wallingford CT, US
Shaojing Hu - Hamden CT, US
Assignee:
The Institute for Pharmaceutical Discovery LLC - Branford CT
International Classification:
C07D 471/00
C07D 498/00
C07D 513/00
C07D 405/00
C07D 307/87
US Classification:
546 85, 546 86, 546 87, 546112, 548454, 548465, 548491, 549460
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I):.

Phenyl Substituted Carboxylic Acids

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US Patent:
7465825, Dec 16, 2008
Filed:
Nov 18, 2005
Appl. No.:
11/283437
Inventors:
Michael C. Van Zandt - Guilford CT, US
Haiquan Fang - Madison CT, US
Shaojing Hu - Hamden CT, US
Darren Whitehouse - Westbrook CT, US
Assignee:
The Institute for Pharmaceutical Discovery, LLC - Branford CT
International Classification:
C07C 229/00
C07D 333/00
C07D 307/91
A01N 43/12
A01N 43/08
US Classification:
562450, 549 48, 549461, 514443, 514468
Abstract:
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):.

Substituted Amino Carboxylic Acids

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US Patent:
7498356, Mar 3, 2009
Filed:
Nov 18, 2005
Appl. No.:
11/283456
Inventors:
Darren Whitehouse - Westbrook CT, US
Shaojing Hu - Hamden CT, US
Michael C. Van Zandt - Guilford CT, US
Garrett Parker - Branford CT, US
Assignee:
The Institutes for Pharmaceutical Discovery LLC - Branford CT
International Classification:
A61K 31/343
C07D 307/91
US Classification:
514468, 549460, 549461
Abstract:
Disclosed are compound and pharmaceutically acceptable salts of formula (I):.

Phenyl Substituted Carboxylic Acids

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US Patent:
7524878, Apr 28, 2009
Filed:
Apr 30, 2004
Appl. No.:
10/835924
Inventors:
Darren Whitehouse - Westbrook CT, US
Shaojing Hu - Hamden CT, US
Haiquan Fang - Madison CT, US
Michael C. Van Zandt - Guilford CT, US
Assignee:
The Institute for Pharmaceuticals Discovery LLC - Branford CT
International Classification:
A61K 31/341
A61K 31/404
C07D 209/04
C07D 307/79
US Classification:
514419, 514468, 514469, 548490, 549461, 549462
Abstract:
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):.

Substituted Phenylalkanoic Acids For The Treatment Of Diabetes

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US Patent:
20040248937, Dec 9, 2004
Filed:
Apr 14, 2004
Appl. No.:
10/824057
Inventors:
Michael Van Zandt - Guilford CT, US
Haiguan Fang - Madison CT, US
Shaojing Hu - Hamden CT, US
Darren Whitehouse - Westbrook CT, US
Assignee:
The Institute for Pharmaceutical Discovery LLC
International Classification:
C07D211/34
A61K031/4965
A61K031/445
A61K031/40
A61K031/19
US Classification:
514/317000, 514/408000, 514/568000, 546/229000, 546/238000, 548/577000, 562/450000, 514/567000
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.

Substituted Heteroaryls

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US Patent:
20050009817, Jan 13, 2005
Filed:
Apr 30, 2004
Appl. No.:
10/836371
Inventors:
Jennifer Savoy - Clinton CT, US
Leo Geraci - Clinton CT, US
Garrett Parker - Branford CT, US
Michael Van Zandt - Guilford CT, US
Darren Whitehouse - Westbrook CT, US
Shaojing Hu - Hamden CT, US
International Classification:
A61K031/541
A61K031/5377
A61K031/496
A61K031/454
US Classification:
514227500, 514235500, 514252130, 514256000, 514326000, 514365000, 514374000, 514397000, 514408000, 544060000, 544124000, 544359000, 546207000, 548181000, 548215000, 548311100, 548516000
Abstract:
Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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Darren L Whitehouse from Westbrook, CT, age ~56 Get Report