Danton K Leung

6517778, Feb 11, 2003

Jul 26, 1999

09/361391

Amit Kumar - Milpitas CA
Larry Sheldon Jang - San Jose CA
Danton Kai-Yu Leung - Los Altos CA
Richard Michele Rocco - Sunnyvale CA
Mark Charles Platshon - Menlo Park CA

IDEXX Laboratories - Westbrook ME

G01N 2147

422 8205, 436527, 422 681, 422101, 422104, 422100, 422 64, 422 8208

A fluorescent immunoassay employing the interior surface of a capillary tube is provided. Devices to permit immunoassays using one or more capillary tubes, an apparatus for use with the devices, and a process for screening for analyte in a sample using the devices and apparatus are also provided. Samples suspected of containing analyte are added to a disposable self-contained sample tray containing one or more sample wells, mixed with a reagent, drawn into one or more spaced-apart capillary tubes held within a disposable cartridge connected to an analytical apparatus, reacted with a binding member on the surface of the capillary tube, washed to stop the reaction, and dried by the apparatus. The capillary tube is then exposed to a signal generation device to create a fluorescence signal that is detected using a signal detector. The apparatus determines the presence of the analyte and optionally determines the amount of analyte present in the sample, and presents the results to the operator.

20020148728, Oct 17, 2002

Dec 28, 2001

10/034424

Amit Kumar - Milpitas CA, US
Larry Jang - San Jose CA, US
Danton Leung - Los Altos CA, US
Richard Rocco - Sunnyvale CA, US
Mark Platshon - Menlo Park CA, US

IDEXX Laboratories, Inc.

G01F001/64
C12M001/34

204/451000, 435/287200

A fluorescent immunoassay employing the interior surface of a capillary tube is provided. Devices to permit immunoassays using one or more capillary tubes, an apparatus for use with the devices, and a process for screening for analyte in a sample using the devices and apparatus are also provided. Samples suspected of containing analyte are added to a disposable self-contained sample tray containing one or more sample wells, mixed with a reagent, drawn into one or more spaced-apart capillary tubes held within a disposable cartridge connected to an analytical apparatus, reacted with a binding member on the surface of the capillary tube, washed to stop the reaction, and dried by the apparatus. The capillary tube is then exposed to a signal generation device to create a fluorescence signal that is detected using a signal detector. The apparatus determines the presence of the analyte and optionally determines the amount of analyte present in the sample, and presents the results to the operator.

42383897, Dec 9, 1980

Feb 12, 1979

6/011254

Danton K. Leung - San Jose CA
Prithipal Singh - Santa Clara CA

Syva Company - Palo Alto CA

C07C10352
A23J 100
C07G 700

2601125R

alpha. -substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.

42207223, Sep 2, 1980

Feb 10, 1978

5/876772

Gerald L. Rowley - San Jose CA
Danton Leung - Campbell CA

Syva Company - Palo Alto CA

C12N 996

435188

Methods and compositions are provided for conjugating a wide variety of compounds, particularly polyfunctional compounds, having a mercapto group, either naturally present or synthetically introduced, to a polyamino compound, particularly a polypeptide (including proteins). The method employs a haloalkylcarbonyl compound, which is conjugated to one or more of the amino groups under mild acylating conditions. This is followed by combining the acylated polyamino compound with a mercapto containing compound, whereby the halogen is displaced by the sulfur of the mercapto group to form a stable thioether linkage. The resulting conjugates, depending on the compounds involved, can find uses in immunoassays, as hapten-antigen conjugates for the production of antibodies, and as ligand analog enzyme conjugates for use as reagents in controlling the distribution of substitution of a mercapto compound to a polyamino compound.

44093250, Oct 11, 1983

Dec 21, 1981

6/332630

Danton K. Leung - San Jose CA
Prithipal Singh - Santa Clara CA

Syva Company - Palo Alto CA

G01N 3354
C12N 996
A61K 3900

435 7

alpha. -substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.

59768967, Nov 2, 1999

Jul 29, 1996

8/688043

Amit Kumar - Milpitas CA
Larry Sheldon Jang - San Jose CA
Danton Kai-Yu Leung - Los Altos CA
Richard Michele Rocco - Sunnyvale CA
Mark Charles Platshon - Menlo Park CA

Idexx Laboratories, Inc. - Westbrook ME

G01N 3302

436527

A fluorescent immunoassay employing the interior surface of a capillary tube is provided. Devices to permit immunoassays using one or more capillary tubes, an apparatus for use with the devices, and a process for screening for analyte in a sample using the devices and apparatus are also provided. Samples suspected of containing analyte are added to a disposable self-contained sample tray containing one or more sample wells, mixed with a reagent, drawn into one or more spaced-apart capillary tubes held within a disposable cartridge connected to an analytical apparatus, reacted with a binding member on the surface of the capillary tube, washed to stop the reaction, and dried by the apparatus. The capillary tube is then exposed to a signal generation device to create a fluorescence signal that is detected using a signal detector. The apparatus determines the presence of the analyte and optionally determines the amount of analyte present in the sample, and presents the results to the operator.

43235077, Apr 6, 1982

Jul 14, 1980

6/168867

Danton K. Leung - San Jose CA
Prithipal Singh - Santa Clara CA

Syva Company - Palo Alto CA

C07D30910
C07C 5974
C07C 5502

2603459R

alpha. -substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.

45967687, Jun 24, 1986

Nov 2, 1983

6/548164

Prithipal Singh - Sunnyvale CA
Danton K. Leung - San Jose CA
Richard Rodgers - Palo Alto CA

Syntex (U.S.A.) Inc. - Palo Alto CA

G01N 3353
C07K 1506
A61K 3900
C12Q 100

435 7

Conjugates of penicilloic acid derivatives and certain poly(amino acids), which are either antigenic or enzymatic, are provided. Antibodies raised against the antigenic poly(amino acids) and the enzyme conjugates are used as reagents in immunoassays. In particular, the compounds of the present invention can be used for measuring the presence of a. beta. -lactamase in a patient serum sample by adding a known amount of penicillin to the sample and observing the production of penicilloic acid over a fixed period of time.