US Patent:
20150017099, Jan 15, 2015
Inventors:
- Philadelphia PA, US
Robert J. Lee - Pittsburgh PA, US
Danielle R. Reed - Glenside PA, US
International Classification:
A61K 36/185
A61K 31/365
A61K 45/06
G01N 33/68
A61K 31/4709
C12Q 1/68
G01N 33/50
A61K 31/167
A61K 31/513
US Classification:
424 91, 514620, 514468, 514571, 514 33, 514 27, 514280, 514 40, 514 29, 51421015, 514206, 514202, 514204, 514201, 514203, 514 24, 514 29, 514274, 435 611, 506 9, 435 721, 514473, 506 10, 514305, 424725
Abstract:
The invention provides methods and compositions for the diagnosis, prognosis and treatment of respiratory tract diseases. Specifically, the invention provides diagnosis, prognosis and treatment of respiratory infections using bitter and sweet taste signal transduction pathways. In one aspect, the invention relates to a method for treating a respiratory infection by administering a composition to the respiratory tract of a subject in an amount capable of activating bitter taste signaling and/or inhibiting sweet taste signaling. The composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract. In another aspect, the invention relates to a composition for treatment of a respiratory infection. Such composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract.