Resumes
Resumes
Daniela Salvemini Phones & Addresses
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1820 Orchard Hill Dr, Chesterfield, MO 63017 (636) 519-8419
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400 Stallion Hill Ct, Chesterfield, MO 63005 (636) 519-8419
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Ballwin, MO
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1820 Orchard Hill Dr, Chesterfield, MO 63017 (314) 229-0173
Work
Position:
Executive, Administrative, and Managerial
Emails
Publications
Us Patents
Polyethylene Glycolated Superoxide Dismutase Mimetics
View pageUS Patent:
8217166, Jul 10, 2012
Filed:
Jun 21, 2007
Appl. No.:
11/766221
Inventors:
Daniela Salvemini - Chesterfield MO, US
William L. Neumann - St. Louis MO, US
Samuel Tremont - St. Louis MO, US
Kishore Udipi - Santa Rosa CA, US
Amruta Reddy Poreddy - St. Louis MO, US
William L. Neumann - St. Louis MO, US
Samuel Tremont - St. Louis MO, US
Kishore Udipi - Santa Rosa CA, US
Amruta Reddy Poreddy - St. Louis MO, US
Assignee:
Galera Therapeutics, LLC - St. Louis MO
International Classification:
C07B 47/00
C07D 487/22
C07D 487/22
US Classification:
540145
Abstract:
Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
Method Of Preventing And Treating Hiv-Mediated Central Nervous System Damage
View pageUS Patent:
20020072512, Jun 13, 2002
Filed:
Sep 13, 2001
Appl. No.:
09/951855
Inventors:
Daniela Salvemini - Chesterfield MO, US
Assignee:
Metaphore Pharmaceuticals, Inc
International Classification:
A61K031/555
US Classification:
514/184000, 514/185000
Abstract:
The present invention relates to methods of preventing and/or treating HIV-mediated central nervous system damage. The method comprises administering to a subject therapeutic amounts of non-proteinaceous catalysts for the dismutation of superoxide to a subject either alone or in combination with a HIV anti-viral agent. The compounds of the invention are particularly suitable for treating and/or preventing AIDS Dementia Complex.
Sodm Therapy For Prevention And/Or Treatment Of Inflammatory Disease
View pageUS Patent:
20020128248, Sep 12, 2002
Filed:
Nov 30, 2001
Appl. No.:
09/997974
Inventors:
Daniela Salvemini - Chesterfield MO, US
Assignee:
MetaPhore Pharmaceuticals, Inc
International Classification:
A61K031/555
US Classification:
514/185000, 540/465000
Abstract:
The present invention relates to pharmaceutical compositions and methods using such compositions for the treatment of inflammatory disease, specifically rheumatoid arthritis. Such compositions contain a catalyst for the dismutation of superoxide which is a low molecular weight organic ligand derived metal complexes that function as mimics of the superoxide dismutase enzyme (SOD mimetics or SODms).
Composition Comprising A Catalyst For The Dismutation Of Superoxide And Use Of The Composition For Preventing And Treating Hypotension
View pageUS Patent:
20040132706, Jul 8, 2004
Filed:
Apr 25, 2003
Appl. No.:
10/398705
Inventors:
Daniela Salvemini - Chesterfield MO, US
International Classification:
A61K031/555
US Classification:
514/184000, 540/465000
Abstract:
The present invention relates to pharmaceutical and veterinary compositions and methods using such compositions for the treatment of hypotension. Such compositions contain a catalyst for the dismutation of superoxide, including superoxide dismutase enzyme (SOD) and small molecular weight organic ligand mimics of that enzyme (SOD mimetics or SODms) which may be administered alone or in combination with a catecholamine pressor agent. Applications described include treatments for hypotension resulting from septic, cardiogenic, hypovolemic, anaphylactic or burn-induced shock treatments.
Combinations Of Superoxide Dismutase Mimetics And Nonsteroidal Analgesic / Anti-Inflammatory Drugs
View pageUS Patent:
20040147498, Jul 29, 2004
Filed:
Dec 16, 2003
Appl. No.:
10/739814
Inventors:
Daniela Salvemini - Chesterfield MO, US
International Classification:
A61K031/60
A61K031/555
A61K031/415
A61K031/555
A61K031/415
US Classification:
514/184000, 514/406000, 514/165000, 514/570000
Abstract:
Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic/Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
Combinations Of Superoxide Dismutase Mimetics And Opioids
View pageUS Patent:
20040219138, Nov 4, 2004
Filed:
Dec 16, 2003
Appl. No.:
10/738578
Inventors:
Daniela Salvemini - Chesterfield MO, US
International Classification:
A61K038/44
A61K031/555
A61K031/485
A61K031/555
A61K031/485
US Classification:
424/094400, 514/184000, 514/282000
Abstract:
Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and opioids are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
Combination Therapy Of An Sodm And A Corticosteroid For Prevention And/Or Treatment Of Inflammatory Disease
View pageUS Patent:
20040266742, Dec 30, 2004
Filed:
Jun 2, 2004
Appl. No.:
10/481396
Inventors:
Daniela Salvemini - Chesterfield MO, US
International Classification:
A61K031/573
A61K031/555
A61K031/555
US Classification:
514/171000, 514/184000
Abstract:
The present invention relates to pharmaceutical compositions and methods using such compositions for the treatment of inflammatory disease. Such compositions contain a catalyst for the dismutation of superoxide, including superoxide dismutase enzyme (SOD) and low molecular weight organic ligand derived metal complexes characterized in having the following structure: (Z)that function as mimics of the enzyme (SOD mimetics or SODm) in combination with corticosteroids.
Sodm Therapy For Treatment, Prevention, Inhibition And Reversal Of Inflammatory Disease
View pageUS Patent:
20050171198, Aug 4, 2005
Filed:
Oct 21, 2004
Appl. No.:
10/971799
Inventors:
Daniela Salvemini - Chesterfield MO, US
International Classification:
A61K031/35
A01N043/16
A01N043/16
US Classification:
514492000
Abstract:
The present invention relates to the use of a manganese complex of a heterocyclic pentaazacyclopentadecane ligand, which is effective as a catalyst for dismutating superoxide, particularly in treating, preventing, inhibiting and reversing inflammatory disease.