Dalia S Cohen

20020174446, Nov 21, 2002

Sep 27, 2001

09/964899

Dalia Cohen - Livingston NJ, US
Uwe Dengler - Loerrach, DE
Alyce Finelli - Parsippany NJ, US
Felix Freuler - Riehen, CH
Mary Konsolaki - Westfield NJ, US
Mischa Reinhardt - Bantzenheim, FR
Susan Zusman - Sudbury MA, US

A01K067/033
A61K031/00

800/008000, 514/001000

Transgenic flies displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these flies in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.

20040038324, Feb 26, 2004

May 19, 2003

10/432072

Peter Atadja - Parsippany NJ, US
Markus Wartmann - Riehen, CH
Yan Yan-Neale - Edison NJ, US
Dalia Cohen - Livingston NJ, US

G01N033/574
C12N005/08

435/007230, 435/366000

Epothilone resistant cells lines are disclosed. The invention also discloses methods for identifying substances which are cytotoxic to epothilone resistant cells or which are chemosensitizers or analogs of epothilone. The invention further discloses methods for identifying epothiolone resistant cells and for inhibiting the growth of epothilone resistant cells in vitro and in vivo. The invetion also discloses antibodies specific for epothilone resistant cells. Also disclosed is a method to identify microtubule stabilizing agents using the epothilone resistant cell lines disclosed.

20040077046, Apr 22, 2004

Nov 4, 2003

10/451316

Dalia Cohen - Livingston NJ, US
Umesh Bhatia - San Jose CA, US
Richard Cai - Bridgewater NJ, US
Denise Fischer - Bernardsville NJ, US

C07H021/04
C12N009/16
C07K014/47

435/069100, 435/320100, 435/196000, 435/325000, 530/350000, 536/023200

Disclosed is an HDAC related genes and gene products. In particular, the invention relates to a protein and variants that is highly homologous to known HDACs and referred to herein as HDAC9, nucleic acid molecules that encode such a protein, antobodies that recognize the protein, and methods for diagnosing conditions related to abnormal HDAC9 activity or gene expression.

20050138676, Jun 23, 2005

Oct 28, 2004

10/975523

Dalia Cohen - Livingston NJ, US
Uwe Dengler - Loerrach, DE
Alyce Finelli - Parsippany NJ, US
Felix Freuler - Riehen, CH
Mary Konsolaki - Westfield NJ, US
Mischa Reinhardt - Bantzenheim, FR
Susan Zusman - Sudbury MA, US

A01K067/033

800008000

Transgenic flies displaying altered phenotypes due to expression of the Abeta and Cportions of the human APP gene are disclosed. Use of these flies in a method to identify genes and the human homologs of these genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.

20060135412, Jun 22, 2006

Nov 21, 2003

10/535385

Dalia Cohen - Livingston NJ, US
Larry Gaither - Bradford MA, US

A61K 38/17
A61K 38/12
A61K 48/00

514009000, 514012000, 514044000

The invention discloses previously unknown modifiers of Aβ secretion. These proteins are identified as suitable targets for the development of new therapeutics to treat, prevent or ameliorate pathological conditions associated with Aβ secretion, including Alzheimer's Disease. The invention also relates to methods to treat, prevent or ameliorate said pathological conditions and pharmaceutical compositions therefore comprising modulators with inhibitory effects on the activity and/or expression of these modifiers.

20070134744, Jun 14, 2007

Jan 5, 2007

11/650375

Peter Atadja - Parsippany NJ, US
Markus Wartmann - Riehen, CH
Yan Yan-Neale - Edison NJ, US
Dalia Cohen - Livingston NJ, US

G01N 33/574
C12N 5/08
A61K 31/427

435007230, 435366000, 514365000

Epothilone resistant cells lines are disclosed. The invention also discloses methods for identifying substances which are cytotoxic to epothilone resistant cells or which are chemosensitizers or analogs of epothilone. The invention further discloses methods for identifying epothilone resistant cells and for inhibiting the growth of epothilone resistant cells in vitro and in vivo. The invention also discloses antibodies specific for epothilone resistant cells. Also disclosed is a method to identify microtubule stabilizing agents using the epothilone resistant cell lines disclosed.