US Patent:
20090105125, Apr 23, 2009
Inventors:
Hongmei Zhao - Northborough MA, US
Nelson S. Yew - West Upton MA, US
Seng H. Cheng - Natick MA, US
Canwen Jiang - Southborough MA, US
Cynthia Marie Arbeeny - Westborough MA, US
International Classification:
A61K 31/40
A61K 31/16
A61K 31/4025
A61K 38/28
A61K 31/357
US Classification:
514 4, 514613, 514452, 514408, 514422
Abstract:
The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.