Inventors:
Robert Levy - Merion Station PA, US
Ivan Alferiev - Clementon NJ, US
Cunxian Song - Philadelphia PA, US
Llia Fishbein - Philadelphia PA, US
Assignee:
The Children's Hospital of Philadelphia
International Classification:
A61K039/395
A61K038/40
A61K031/4188
A61K038/17
US Classification:
424/130100, 424/423000, 514/006000, 514/012000, 514/393000
Abstract:
A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer that can fasten various molecules, thereby minimizing any cellular inflammatory response while enhancing biocompatibility.