US Patent:
20030059889, Mar 27, 2003
Inventors:
Dale Bodian - Whippany NJ, US
Mark Labow - Westfield NJ, US
Craig Mickanin - Basking Ridge NJ, US
International Classification:
C12Q001/68
C07H021/04
C07K014/715
C12P021/02
C12N005/06
US Classification:
435/069100, 435/320100, 435/325000, 530/350000, 536/023500, 435/006000
Abstract:
Disclosed is a tumor necrosis factor receptor related protein 1 gene and gene product. In particular, the invention relates to a protein that is homologous to known tumor necrosis factor receptors, nucleic acid molecules that encode such a protein, antibodies that recognize the protein, methods for diagnosing and treating disorders, such as inflammatory disorders, immune disorders, neurodegenerative disorders, cell proliferative disorders, cell differentiation disorders, apoptotic disorders, gastrointestinal and reproductive tract disorders, bone disorders, blood disorders and viral disorders, methods of identifying molecules that bind and/or modulate the activity of TRP-1 protein, and methods of identifying molecules that bind to a nucleic acid encoding TRP-1 protein and/or modulate the transcription or translation of the nucleic acid encoding TRP-1 protein.