Clark M Edson

6352695, Mar 5, 2002

Oct 3, 1997

08/943643

Edward I. Budowsky - Brookline MA
Samuel K. Ackerman - Weston MA
Andrei A. Purmal - Waltham MA
Clark M. Edson - Somerville MA

V.I. Technologies, Inc. - Watertown MA

A61K 3912

4242041, 4242111, 4242291, 4242321, 4242331, 424529, 4352351, 435236, 435238, 514642, 514183

Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R , R , R , R , R , R , and R is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R , R , R , R , R , R , and R cannot all be H; R is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.

6369048, Apr 9, 2002

Jan 12, 1998

09/005719

Edward I. Budowsky - Brookline MA
Samuel K. Ackerman - Weston MA
Andrei A. Purmal - Waltham MA
Clark M. Edson - Somerville MA
Martin D. Williams - Watertown MA

V.I. Technologies, Inc. - Watertown MA

A61K 3133

514183, 514144, 514148, 514473, 514720, 514723

Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.

6617101, Sep 9, 2003

Sep 6, 2000

09/656243

Clark M. Edson - Somerville MA
Andrei A. Purmal - Waltham MA
Samuel K. Ackerman - Weston MA

V. I. Technologies, Inc. - Watertown MA

A01N 102

435 2, 435 11, 422 28, 422 30, 422 44

Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of ethyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.

6617157, Sep 9, 2003

Dec 16, 1998

09/212778

Edward I. Budowsky - Brookline MA
Samuel K. Ackerman - Weston MA
Andrei A. Purmal - Waltham MA
Clark M. Edson - Somerville MA

V.I. Technologies, Inc. - Watertown MA

A61K 3900

435325, 514672, 562 41, 562607, 564510

Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R , R , R , R , R , R , and R is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R , R , R , R , R , R , and R cannot all be H; R is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.

6774123, Aug 10, 2004

Jul 28, 1999

09/362337

Edward I. Budowsky - Brookline MA
Samuel K. Ackerman - Weston MA
Andrei A. Purmal - Waltham MA
Clark M. Edson - Somerville MA
Martin D. Williams - Watertown MA

V.I. Technologies, Inc. - Watertown MA

A61K 3183

514183, 514144, 514148, 514475, 514720, 514723

Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.

8638435, Jan 28, 2014

Jul 27, 2011

13/191813

Louis H. Strong - Duxbury MA, US
Clark M. Edson - Belmont MA, US
Senerath Palamakumbura - Winchester MA, US
Daniel B. Hall - Easton MA, US
Gyula Varadi - Watertown MA, US

Radiation Monitoring Devices, Inc. - Watertown MA

G01N 21/00
G01N 15/02

356337, 356338

The disclosure relates to bioassays, as well as related devices and methods for detecting targets. The targets may be molecules and/or biological products that a user is interested in analyzing to determine information such as their presence and/or concentration in a sample.

20020034724, Mar 21, 2002

Jun 8, 2001

09/877838

Clark Edson - Watertown MA, US
Andrei Purmal - Waltham MA, US
Samuel Ackerman - Weston MA, US

C12N005/08

435/002000, 435/372000

The invention features a method for inactivating microorganisms such as viruses and bacteria in a preparation of purified mammalian cells which, when mature, lack a nucleus (e.g., red blood cells or platelets). The method includes contacting the preparation with ethyleneimine dimer under viral inactivating conditions for a period of time sufficient to inactivate at least some of the microorganismsin the preparation. Also disclosed is a method for removing ethyleneimine dimer from a treated biological composition following inactivation, without the addition of any quenching agent.

20020123480, Sep 5, 2002

Oct 23, 2001

10/000498

Clark Edson - Watertown MA, US
Samuel Ackerman - Weston MA, US

A61K048/00

514/044000

2′,5′-oligoadenylate-2′,3′-cyclophosphates having the chemical structure of Formula I: wherein 0n10, or the pharmaceutically acceptable salts thereof, inhibit cell proliferation and tumor cell growth, and are therefore useful in methods and compositions for the treatment of disorders of cell proliferation, including cancer, and also in the reduction of tumor size.