Inventors:
Ramesh Kumar - Pennington NJ
Ajay Sharma - Lawrenceville NJ
Clara Paulhiac - Princeton NJ
Sunita Midha - Dayton NJ
International Classification:
C07H 2104
C07K 100
C07K 1400
A61K 3514
Abstract:
The present invention relates to the use of transgenic pigs for the production of human hemoglobin. The transgenic pigs of the invention may be used as an efficient and economical source of cell-free human hemoglobin that may be used for transfusions and other medical applications in humans. Also disclosed are the methods of purifying human hemoglobin from pig red cell lysate, and plasmids contained pig and human nucleic acid sequences for the production of transgenic pigs expressing human globin DNA sequences.