Inventors:
Hui Li - Carlsbad CA, US
Seiji Nukui - San Diego CA, US
Stephanie Anne Scales - San Diego CA, US
Min Teng - San Diego CA, US
Chunfeng Yin - San Diego CA, US
Assignee:
Pfizer, Inc. - New York NY
International Classification:
A61K 31/505
US Classification:
514275, 544324, 544386, 546245, 5483605, 549356
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: (A) and (B) wherein A, B, R, R, R, R, R, R, R, R, Rand Rare as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.