US Patent:
20210315968, Oct 14, 2021
Inventors:
- Columbus OH, US
JACOB S. YOUNT - COLUMBUS OH, US
MATTHEW A. SERMERSHEIM - NASHVILLE TN, US
ADAM D. KENNEY - COLUMBUS OH, US
Xinyu ZHOU - HILLIARD OH, US
BRYAN A. WHITSON - WESTERVILLE OH, US
NAHUSH A. MOKADAM - UPPER ARLINGTON OH, US
TAO TAN - COLUMBUS OH, US
CHUANXI CAI - POWELL OH, US
Assignee:
OHIO STATE INNOVATION FOUNDATION - COLUMBUS OH
International Classification:
A61K 38/17
A61K 45/06
Abstract:
Compositions for and methods of preventing, reversing or treating viral infection-induced organ failure provided. The compositions are also suitable for treating and/or preventing COVID-19 and influenza. The compositions and methods employ MG53, which can be in the form of recombinant human MG53. The MG53 may also be administered as a composition that expresses and releases MG53 after in vivo administration of said composition to a subject.