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Christopher J Sevinsky

from Watervliet, NY
Age ~47

Christopher Sevinsky Phones & Addresses

  • 16 Archibald St, Watervliet, NY 12189 (518) 326-9930
  • 16 Lakeshore Dr, Watervliet, NY 12189
  • Lake Pleasant, NY
  • Albany, NY
  • 16 Archibald St, Watervliet, NY 12189

Resumes

Resumes

Christopher Sevinsky Photo 1

Christopher Sevinsky

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Location:
Albany, New York Area
Industry:
Biotechnology
Christopher Sevinsky Photo 2

Christopher Sevinsky

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Publications

Us Patents

Devices, Methods And Systems For Measuring One Or More Characteristics Of A Biomaterial In A Suspension

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US Patent:
20090158822, Jun 25, 2009
Filed:
Dec 21, 2007
Appl. No.:
11/962219
Inventors:
Zongqi Sun - Albany NY, US
Mohan Mark Amaratunga - Clifton Park NY, US
Nicole Lea Wood - Niskayuna NY, US
Christopher James Sevinsky - Watervliet NY, US
Assignee:
GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:
G01N 15/06
G01V 13/00
US Classification:
73 6175, 73 183
Abstract:
A system for measuring one or more ultrasound parameters of a suspension comprising particulate biomaterial dispersed in a liquid carrier comprising, a bioprocessor for processing the particulate biomaterial; an immersible device comprising an ultrasound probes and a reflector; a housing, that fixes the probe and the reflector at positions with a space in between the probe surface and the reflective surface, comprising an opening into the housing that is of a size sufficient to allow the suspension to flow into the space between the probe surface and the reflective surface; an ultrasound wave generator/receiver device; and a signal processing device.

Method And Apparatus For Antigen Retrieval Process

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US Patent:
20110053171, Mar 3, 2011
Filed:
Aug 26, 2009
Appl. No.:
12/547768
Inventors:
Michael John Gerdes - Albany NY, US
Anup Sood - Clifton Park NY, US
Christopher James Sevinsky - Watervliet NY, US
Assignee:
General Electric Company - Schenectady NY
International Classification:
G01N 33/53
C12N 5/08
C12M 1/00
C12M 3/00
US Classification:
435 71, 435366, 4352831, 4352891
Abstract:
The invention provides a method for antigen retrieval of a formaldehyde-fixed tissue sample comprising incubating a formaldehyde-fixed tissue sample in a first antigen retrieval solution at a temperature of greater than 90 C., transferring the tissue sample to a second antigen retrieval solution, and incubating the tissue sample in the second antigen retrieval solution at a temperature of greater than 90 C. The invention also provides a kit and sample delivery device for carrying out the method.

Method And Apparatus For Antigen Retrieval Process

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US Patent:
20120009666, Jan 12, 2012
Filed:
Sep 22, 2011
Appl. No.:
13/239918
Inventors:
Michael John Gerdes - Albany NY, US
Anup Sood - Clifton Park NY, US
Christopher James Sevinsky - Watervliet NY, US
Assignee:
GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:
C12M 1/34
US Classification:
4352872
Abstract:
The invention provides a method for antigen retrieval of a formaldehyde-fixed tissue sample comprising incubating a formaldehyde-fixed tissue sample in a first antigen retrieval solution at a temperature of greater than 90 C., transferring the tissue sample to a second antigen retrieval solution, and incubating the tissue sample in the second antigen retrieval solution at a temperature of greater than 90 C. The invention also provides a kit and sample delivery device for carrying out the method.

Closed Loop Monitoring Of Automated Molecular Pathology System

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US Patent:
20120135458, May 31, 2012
Filed:
Nov 30, 2010
Appl. No.:
12/957203
Inventors:
Alex David Corwin - Niskayuna NY, US
Robert John Filkins - Niskayuna NY, US
Jun Xie - Niskayuna NY, US
Christopher James Sevinsky - Watervliet NY, US
Kashan Ali Shaikh - Clifton Park NY, US
Assignee:
GENERAL ELECTRIC COMPANY - SCHENECTADY NY
International Classification:
G01N 1/30
C12M 1/36
US Classification:
435 405, 4352861
Abstract:
A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.

Analyzing The Expression Of Biomarkers In Cells With Clusters

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US Patent:
20120269418, Oct 25, 2012
Filed:
Oct 3, 2011
Appl. No.:
13/252072
Inventors:
Colin Craig McCulloch - Ballston Lake NY, US
Christopher J. Sevinsky - Watervliet NY, US
Fiona Ginty - Saratoga Springs NY, US
Assignee:
GE Global Research - Niskayuna NY
International Classification:
G06K 9/00
G01N 33/577
US Classification:
382133, 435 71
Abstract:
A data set of cell profile data is stored. The cell profile data includes multiplexed biometric image data describing the expression of a plurality of biomarkers with respect to a field of view in which individual cells are delineated and segmenting into compartments. Each cell in the field is assigned to a single cluster in a selected set of clusters based on cell similarity; cell similarity is determined based on a plurality of selected cell attributes. The proportion of cells in each cluster is observed. The observed proportions are examined for an association with a diagnosis, a prognosis, or a response derived from a known association of the selected set of clusters with at least one piece of meta-information including a field of view level assessment or a patient-level assessment.

Analyzing The Expression Of Biomarkers In Cells With Moments

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US Patent:
20120270752, Oct 25, 2012
Filed:
Oct 3, 2011
Appl. No.:
13/252069
Inventors:
Colin Craig McCulloch - Ballston Lake NY, US
Christopher J. Sevinsky - Watervliet NY, US
Fiona Ginty - Saratoga Springs NY, US
Assignee:
GE Global Research - Niskayuna NY
International Classification:
G06F 19/10
C40B 40/10
G01N 33/573
US Classification:
506 18, 435 71, 702 19
Abstract:
Cell profile data is stored. The cell profile data comprises multiplexed biometric images capturing the expression of a plurality of biomarkers by at least one tissue sample from a patient with respect to at least one field of view. Individual cells are delineated and segmented into compartments. At least one cell feature is calculated based on the cell's expression of each of a plurality of biomarkers. A first moment is calculated for each cell feature. The moments are examined for an association with a diagnosis, a prognosis of a response to treatment of a condition or disease. Apparatus for performing the foregoing steps are disclosed.

Determination Of Spatial Proximity Between Features Of Interest In Biological Tissue

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US Patent:
20140003702, Jan 2, 2014
Filed:
Jun 29, 2012
Appl. No.:
13/539187
Inventors:
Colin Craig McCulloch - Ballston Lake NY, US
Christopher James Sevinsky - Watervliet NY, US
Jingyu Zhang - Rexford NY, US
Assignee:
GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:
G06K 9/46
US Classification:
382134, 382133
Abstract:
Exemplary embodiments enable determination of spatial proximity between two or more features in biological tissue. An exemplary method includes identifying a morphological feature in an image of the biological tissue based on expression levels of a first biomarker indicative of the morphological feature, and receiving a result of a segmentation analysis performed on the image of the biological tissue identifying a set of morphological units in the image external to the morphological feature. An exemplary method includes determining an expression level of a second biomarker corresponding to each unit in the set of morphological units in the image of the biological tissue, and determining a spatial distance between the morphological feature and each unit in the set of morphological units. An exemplary method further includes automatically determining a relationship between expression levels of the second biomarker and corresponding spatial distance from the morphological feature of the set of morphological units.

Systems And Methods For Automatic Generation Of Training Sets For Machine Interpretation Of Images

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US Patent:
20190080146, Mar 14, 2019
Filed:
Sep 13, 2017
Appl. No.:
15/703835
Inventors:
- Schenectady NY, US
Qing Li - Schenectady NY, US
Yunxia Sui - Clifton Park NY, US
Dmitry Vladimirovich Dylov - Clifton Park NY, US
Christopher James Sevinsky - Watervliet NY, US
Michael E. Marino - Albany NY, US
Michael J. Gerdes - Albany NY, US
Daniel Eugene Meyer - Rexford NY, US
Fiona Ginty - Saratoga Springs NY, US
Anup Sood - Clifton Park NY, US
International Classification:
G06K 9/00
G06T 7/33
Abstract:
The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.
Christopher J Sevinsky from Watervliet, NY, age ~47 Get Report