Search

Christopher R Sclimenti

from Waxhaw, NC
Age ~52

Christopher Sclimenti Phones & Addresses

  • 2715 Dombey St, Waxhaw, NC 28173
  • Highland Park, IL
  • Del Mar, CA
  • Laguna Niguel, CA
  • 3141 Via Alicante, La Jolla, CA 92037
  • Los Angeles, CA
  • Burlingame, CA
  • San Jose, CA
  • Newport Beach, CA

Publications

Us Patents

Altered Recombinases For Genome Modification

View page
US Patent:
20080167261, Jul 10, 2008
Filed:
Oct 30, 2007
Appl. No.:
11/928915
Inventors:
Christopher R. Sclimenti - La Jolla CA, US
International Classification:
A61K 31/711
C12N 9/24
C07H 21/04
C12N 15/87
US Classification:
514 44, 435200, 536 232, 435462
Abstract:
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.

Altered Recombinases For Genome Modification

View page
US Patent:
20100190178, Jul 29, 2010
Filed:
Apr 9, 2010
Appl. No.:
12/757846
Inventors:
MICHELE P. CALOS - Menlo Park CA, US
Christopher R. Sclimenti - La Jolla CA, US
International Classification:
C12Q 1/68
C12N 9/00
C07H 21/00
C12N 15/00
US Classification:
435 6, 435183, 536 232, 435440
Abstract:
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.
Christopher R Sclimenti from Waxhaw, NC, age ~52 Get Report