Christopher H Cullander

6714815, Mar 30, 2004

Jan 13, 2003

10/341120

Richard Guy - San Francisco CA
Girish Rao - Rutherford NJ
Christopher Cullander - Berkeley CA
Robert S. Hinz - San Francisco CA
Peretz Glikfeld - Ness-Ziona, IL

The Regents of the University of California - Oakland CA

A61N 130

604 20, 600345, 600347

The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.

57307148, Mar 24, 1998

Sep 26, 1994

8/312400

Richard Guy - San Francisco CA
Girish Rao - San Francisco CA
Peretz Glikfeld - Ness-Ziona, IL
Christopher Cullander - Berkeley CA
Robert S. Hinz - Mill Valley CA

The Regents of the University of California - Oakland CA

A61N 130

604 20

The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.

59112239, Jun 15, 1999

Aug 9, 1996

8/695367

James C. Weaver - Sudbury MA
Tani Chen - Piqua OH
Christopher Cullander - Berkeley CA
Richard Guy - Annecy-le-Vieux, FR
Robert S. Langer - Newton MA
Thomas E. Zewert - Boston MA
Uwe Pliquett - Bielefeld-Grossdornberg, DE
Rita Vanbever - Brussels, BE
Mark R. Prausnitz - Atlanta GA

Massachusetts Institute of Technology - Cambridge MA
The Regents of the University of California - Oakland CA

A61B 1900

128898

A method of modifying epidermis for transport of a material by electroporation includes applying to epidermis an agent that, upon entry into the epidermis, will modify the epidermis to thereby cause and altered rate of transport of a material across the epidermis. Typically, the altered rate will be an increased rate of transport. The epidermis is electroporated, whereby at least a portion of the modifying agent enters the electroporated epidermis, thereby modifying the epidermis to cause an altered rate of transport of a material across the epidermis. In another embodiment, the modifying agent can modify the epidermis to enable measurement and/or monitoring of physiological conditions or change within or beneath the epidermis. The modifying agents can also be employed to facilitate discharge of fluids from within an organism, such as by providing pathways for discharge of fluids from a tumor. Examples of modifying agents include: oxidizing agents; reducing agents; particles, such as optical indicator beads or beads that include drugs to be released into tissue; electrically-charged particles or molecules; etc.

52795438, Jan 18, 1994

Apr 30, 1992

7/879060

Peretz Glikfeld - San Francisco CA
Christopher Cullander - Berkeley CA
Robert S. Hinz - Mill Valley CA
Richard H. Guy - Daley City CA

The Regents of The University of California - Oakland CA

A61N 130

604 20

The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.