Resumes
Resumes
Christophe Filippi
View pageLocation:
Studio City, CA
Christophe Filippi Phones & Addresses
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Studio City, CA
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San Diego, CA
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Sherman Oaks, CA
Publications
Us Patents
Antibody-Cytokine Engrafted Proteins And Methods Of Use In The Treatment Of Cancer
View pageUS Patent:
20200270334, Aug 27, 2020
Filed:
May 22, 2018
Appl. No.:
16/616318
Inventors:
- Basel, CH
Michael DiDonato - San Diego CA, US
Christophe Filippi - Studio City CA, US
Glen Spraggon - San Diego CA, US
Michael DiDonato - San Diego CA, US
Christophe Filippi - Studio City CA, US
Glen Spraggon - San Diego CA, US
International Classification:
C07K 16/10
C07K 14/55
C12N 5/0783
A61K 39/395
A61K 45/06
C12N 5/071
A61P 35/00
C07K 14/55
C12N 5/0783
A61K 39/395
A61K 45/06
C12N 5/071
A61P 35/00
Abstract:
The present disclosure provides for IL2 engrafted into the CDR sequences of an antibody having preferred therapeutic profiles over molecules known and used in the clinic. In particular, the provided antibody cytokine engrafted protein compositions increase or maintain CD8+ T effector cells while reducing the activity of Treg cells. Additionally, provided compositions convey improved half-life, stability and produceability over recombinant human IL2 formulations such as Proleukin.
Antibody-Cytokine Engrafted Proteins And Methods Of Use For Immune Related Disorders
View pageUS Patent:
20200113974, Apr 16, 2020
Filed:
May 22, 2018
Appl. No.:
16/616138
Inventors:
- Basel, CH
Michael DiDonato - San Diego CA, US
Christophe Filippi - Studio City CA, US
Shellly Meeusen - San Diego CA, US
Glen Spraggon - San Diego CA, US
Michael DiDonato - San Diego CA, US
Christophe Filippi - Studio City CA, US
Shellly Meeusen - San Diego CA, US
Glen Spraggon - San Diego CA, US
International Classification:
A61K 38/20
C07K 16/10
C07K 16/46
A61P 37/00
C07K 16/10
C07K 16/46
A61P 37/00
Abstract:
The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.