Christian A Hassig

7271195, Sep 18, 2007

Jun 10, 2004

10/865743

Paul L. Wash - San Diego CA, US
Brandon M. Wiley - Encinitas CA, US
Christian Hassig - San Diego CA, US
James W. Malecha - Libertyville IL, US
Stewart A. Noble - San Diego CA, US

Kalypsys, Inc. - San Diego CA

A61K 31/18
C07C 303/00

514602, 564 84, 564 88

Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

20070135431, Jun 14, 2007

Dec 8, 2006

11/608726

Nicholas Smith - San Diego CA, US
Celine Bonnefous - San Diego CA, US
Joseph Payne - San Diego CA, US
Timothy Hoffman - San Diego CA, US
Paul Wash - San Diego CA, US
Christian Hassig - San Diego CA, US
Shawn Scranton - San Diego CA, US

KALYPSYS, INC - San Diego CA

A61K 31/5377
A61K 31/454
A61K 31/4439
C07D 413/14
C07D 401/14

514235200, 514326000, 514340000, 544124000, 546207000, 546277100

Disclosed herein are carbonyl compounds of having the structural formula: or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

20070135438, Jun 14, 2007

Dec 8, 2006

11/608736

Joseph Payne - San Diego CA, US
Nicholas Smith - San Diego CA, US
Shawn Scranton - San Diego CA, US
Christian Hassig - San Diego CA, US

KALYPSYS, INC. - San Diego CA

A61K 31/53
A61K 31/4965
C07D 253/08
A61K 31/505

514242000, 514255060, 514275000, 544183000, 544330000, 544406000

Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

20180207140, Jul 26, 2018

Jan 28, 2016

15/546165

- La Jolla CA, US
Christian A. HASSIG - La Jolla CA, US
Michael R. JACKSON - La Jolla CA, US
Robert John ARDECKY - La Jolla CA, US
Ian PASS - La Jolla CA, US

A61K 31/437
A61P 35/00

Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.