US Patent:
20090181966, Jul 16, 2009
Inventors:
Shomir Ghosh - Brookline MA, US
Amy M. Elder - Arlington MA, US
Kenneth G. Carson - Princeton NJ, US
Kevin T. Sprott - Boston MA, US
Sean J. Harrison - Belmont MA, US
Frederick A. Hicks - Somerville MA, US
Christelle C. Renou - Somerville MA, US
Dominic Reynolds - Cambridge MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/47
C07D 215/42
A61K 31/5377
A61P 37/08
C07D 413/06
US Classification:
5142352, 546160, 544128, 514313
Abstract:
Disclosed herein are compounds represented by Structural Formula (I) and (I-A):Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.