Resumes
Resumes
Chiara Cirelli Phones & Addresses
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Verona, WI
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4175 Bachman Pl, San Diego, CA 92103
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Escondido, CA
Publications
Us Patents
Methods For Identifying Compounds That Modulate Vigilance States
View pageUS Patent:
7468178, Dec 23, 2008
Filed:
Apr 22, 2004
Appl. No.:
10/830909
Inventors:
Giulio Tononi - San Diego CA, US
Chiara Cirelli - San Diego CA, US
Paul J. Shaw - San Diego CA, US
Ralph J. Greenspan - Coronado CA, US
Chiara Cirelli - San Diego CA, US
Paul J. Shaw - San Diego CA, US
Ralph J. Greenspan - Coronado CA, US
Assignee:
Neurosciences Research Foundation, Inc. - San Diego CA
International Classification:
A61K 49/00
US Classification:
424 92, 424 111, 424 91
Abstract:
The invention provides a method of identifying a compound that alters vigilance. The method consists of contacting an invertebrate with a candidate compound, evaluating a vigilance property in the contacted invertebrate, and determining if the candidate compound alters the vigilance property in the contacted invertebrate. A candidate compound that alters the vigilance property in the contacted invertebrate is identified as a compound that alters vigilance. The invention also provides a method of identifying a vigilance enhancing compound that modulates homeostatic regulation or a vigilance diminishing compound that modulates homeostatic regulation. The method consists of contacting an invertebrate with a compound that increases or decreases vigilance, and determining the effect of the compound on a homeostatic regulatory property of vigilance. A compound that alters the homeostatic regulatory property is characterized as being a vigilance enhancing compound or a vigilance diminishing compound that modulates homeostatic regulation.
Vigilance Nucleic Acids And Related Diagnostic, Screening And Therapeutic Methods
View pageUS Patent:
20020042054, Apr 11, 2002
Filed:
Dec 8, 2000
Appl. No.:
09/733607
Inventors:
Giulio Tononi - Escondido CA, US
Chiara Cirelli - Escondido CA, US
Paul Shaw - San Diego CA, US
Ralph Greenspan - Coronado CA, US
Chiara Cirelli - Escondido CA, US
Paul Shaw - San Diego CA, US
Ralph Greenspan - Coronado CA, US
International Classification:
C12Q001/68
C07H021/04
A61K031/00
C07H021/04
A61K031/00
US Classification:
435/006000, 514/001000, 536/023200
Abstract:
The invention provides novel isolated vigilance nucleic acid molecules, and kits containing two or more isolated vigilance nucleic acid molecules. Methods for diagnosing and treating vigilance disorders, for determining and altering vigilance levels, and for screening for therapeutic compounds useful for treating vigilance disorders and altering vigilance level, are also provided. The diagnostic, therapeutic and screening methods of the invention involve determining expression or activity profiles of vigilance genes.
Ion Channels As Targets For Sleep-Related Drugs
View pageUS Patent:
20040143855, Jul 22, 2004
Filed:
Dec 23, 2003
Appl. No.:
10/745210
Inventors:
Giulio Tononi - Verona WI, US
Chiara Cirelli - Verona WI, US
Chiara Cirelli - Verona WI, US
International Classification:
A01K067/033
US Classification:
800/008000
Abstract:
The invention provides screening methods for isolating short sleep, no rebound and sleep deprivation resistant Drosophila mutants. Such mutants are further useful to facilitate identification of sleep-related molecular targets. The invention also encompasses methods for identifying a sleep or wakefulness-promoting compound based on the compound's ability to modulate two pore domain K+ channels.
Sleep Genes In Drosophila And Their Use For The Screening, Diagnosis And Therapy Of Sleep Disorders
View pageUS Patent:
20050166269, Jul 28, 2005
Filed:
Dec 15, 2004
Appl. No.:
11/013314
Inventors:
Giulio Tononi - Verona WI, US
Chiara Cirelli - Verona WI, US
Chiara Cirelli - Verona WI, US
International Classification:
A01K067/033
US Classification:
800003000, 435004000, 800008000
Abstract:
Methods of screening for a sleep altering compositions are disclosed as are the identities of various gene products that are involved in sleep function/dysfunction. Also described are methods for modifying the need for sleep and the response to sleep deprivation in subjects.
Methods For Identifying Compounds That Modulate Vigilance States
View pageUS Patent:
6730287, May 4, 2004
Filed:
Nov 22, 2000
Appl. No.:
09/718828
Inventors:
Giulio Tononi - Escondido CA
Chiara Cirelli - Escondido CA
Paul J. Shaw - San Diego CA
Ralph J. Greenspan - Coronado CA
Chiara Cirelli - Escondido CA
Paul J. Shaw - San Diego CA
Ralph J. Greenspan - Coronado CA
Assignee:
Neurosciences Research Foundation Inc. - San Diego CA
International Classification:
A61K 4900
US Classification:
424 92, 424 91
Abstract:
The invention provides a method of identifying a compound that alters vigilance. The method consists of contacting an invertebrate with a candidate compound, evaluating a vigilance property in the contacted invertebrate, and determining if the candidate compound alters the vigilance property in the contacted invertebrate. A candidate compound that alters the vigilance property in the contacted invertebrate is identified as a compound that alters vigilance. The invention also provides a method of identifying a vigilance enhancing compound that modulates homeostatic regulation or a vigilance diminishing compound that modulates homeostatic regulation. The method consists of contacting an invertebrate with a compound that increases or decreases vigilance, and determining the effect of the compound on a homeostatic regulatory property of vigilance. A compound that alters the homeostatic regulatory property is characterized as being a vigilance enhancing compound or a vigilance diminishing compound that modulates homeostatic regulation.
New Uses Of Ganaxolone
View pageUS Patent:
20170182061, Jun 29, 2017
Filed:
Mar 16, 2017
Appl. No.:
15/460382
Inventors:
- MADISON WI, US
CHIARA CIRELLI - VERONA WI, US
KILE PATRICK MANGAN - MADISON WI, US
AARON B. NELSON - NEW YORK NY, US
CHIARA CIRELLI - VERONA WI, US
KILE PATRICK MANGAN - MADISON WI, US
AARON B. NELSON - NEW YORK NY, US
International Classification:
A61K 31/57
Abstract:
Absence epilepsy, a form of epilepsy characterized by nonconvulsive seizures, has proven to be refractive to conventional epilepsy therapies. It has been found that low doses of ganaxolone can be used to reduce absence seizures in subjects with absence epilepsy, particularly pediatric subjects. In addition, ganaxolone therapy is particularly useful in subjects with absence epilepsy characterized by a reduction in tonic inhibition. Low dose ganaxolone is also used to reduce sleep disruptions and to treat sleep disorders in subjects in need of such treatment.
New Uses Of Ganaxolone
View pageUS Patent:
20150335659, Nov 26, 2015
Filed:
May 21, 2015
Appl. No.:
14/718524
Inventors:
- MADISON WI, US
CHIARA CIRELLI - VERONA WI, US
KILE PATRICK MANGAN - MADISON WI, US
AARON B. NELSON - NEW YORK NY, US
CHIARA CIRELLI - VERONA WI, US
KILE PATRICK MANGAN - MADISON WI, US
AARON B. NELSON - NEW YORK NY, US
International Classification:
A61K 31/57
C12Q 1/68
A61K 49/00
C12Q 1/68
A61K 49/00
Abstract:
Absence epilepsy, a form of epilepsy characterized by nonconvulsive seizures, has proven to be refractive to conventional epilepsy therapies. It has been found that low doses of ganaxolone can be used to reduce absence seizures in subjects with absence epilepsy, particularly pediatric subjects. In addition, ganaxolone therapy is particularly useful in subjects with absence epilepsy characterized by a reduction in tonic inhibition. Low dose ganaxolone is also used to reduce sleep disruptions and to treat sleep disorders in subjects in need of such treatment.