Inventors:
Rainer Albert - Basel, CH
Wilfried Bauer - Lampenberg, CH
Christian Bruns - Freiburg, DE
Nagarajan Chandramouli - Morristown NJ
Ian Lewis - Riehen, CH
Gisbert Weckbecker - Biel-Benken, CH
International Classification:
A61K 3808
A61K 3812
C07K 706
C07K 764
Abstract:
Somatostain analogues comprising the amino acid sequence of the formula (I): -(D/L)Trp-Lys-X. sub. 1 -X. sub. 2, wherein X. sub. 1 is a substituted Thr, Ser, Tyr, Glu or Cys residue and X. sub. 2 is an. alpha. -amino acid having an aromatic residue on the C. sub. alpha. side chain, or an amino acid unit selected from Dab, Dpr, Dpm, His (Bzl)HyPro, thienyl-Ala, cyclohexyl-Ala and t. -butyl-Ala, the residue Lys of said sequence corresponding to the residue Lys. sup. 9 of the native somatostatin-14, in free form, in salt form or complexed with a detectable element have interesting pharmacological properties.