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Chafen Lu

from Chestnut Hill, MA
Age ~61
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Related to:
Jie ZhangQian Liu, 52Lu L Yang, 52Tuong Vinh LuZhaohui H Lu, 60Ai Zhang, 57Xiang L Xiaoxiang, 75Enyi Lu, 66Hai R Zhang, 54
Connected to:
Aiyan Lu, 33Alisha Lu, 36Anita Lu, 42Anne C Lu, 85Audriana Lu, 35Bob H Lu, 64Bochao Lu, 34Bowen K Lu, 31Bryant D Lu, 69Cante V Lu, 60

Chafen Lu Phones & Addresses

  • 36 Woodman Rd, Chestnut Hill, MA 02467 (617) 505-5308
  • 290 Commonwealth Ave, Boston, MA 02115
  • 115 Saint Stephen St, Boston, MA 02115
  • Berkeley, CA
  • 3426 62Nd St, Flushing, NY 11377
  • Woodside, NY
  • Astoria, NY
  • Boston Clg, MA
  • 36 Woodman Rd, Chestnut Hill, MA 02467

Resumes

Resumes

Chafen Lu Photo 1

Assistant Professor

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Location:
Boston, MA
Industry:
Research
Work:
Guidepoint
Advisor
Harvard Medical School Oct 2005 - Oct 2015
Instructor
Harvard Medical School Oct 2005 - Oct 2015
Assistant Professor
Takeda Oncology Jul 1998 - Sep 2004
Senior Scientist
Education:
The Graduate School of the City University of New York 1989 - 1994
Doctorates, Doctor of Philosophy, Biology, Philosophy
Skills:
Cell Adhesion
Protein Kinases
Molecular and Cellular Biology
Protein Chemistry
Immunology
Cell Biology
Biochemistry
Molecular Biology
Immunoassays
Antibody Engineering
Protein Engineering
Protein Structure
Monoclonal Antibody Generation
Malaria Vaccines
Research
Structural Biology
Vaccines
Protein Protein Interactions
Monoclonal Antibodies
Certifications:
Leading With Finance Certificate of Completion
Negotiation Mastery Certificate of Completion
Chafen Lu Photo 2

Chafen Lu

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Location:
Boston, MA
Industry:
Biotechnology
Chafen Lu Photo 3

Investigator At Harvard Medical School

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Location:
Greater Boston Area
Industry:
Research

Publications

Us Patents

Modified Polypeptides Stabilized In A Desired Conformation And Methods For Producing Same

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US Patent:
7241869, Jul 10, 2007
Filed:
Mar 15, 2005
Appl. No.:
11/080026
Inventors:
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Chafen Lu - Newton MA, US
Assignee:
Center for Blood Research, Inc. - Boston MA
International Classification:
C07K 14/705
C07K 1/107
US Classification:
530350, 530402
Abstract:
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Modified Polypeptides Stabilized In A Desired Conformation And Methods For Producing Same

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US Patent:
7674604, Mar 9, 2010
Filed:
Mar 15, 2005
Appl. No.:
11/080043
Inventors:
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Chafen Lu - Newton MA, US
Assignee:
The Center for Blood Research, Inc. - Boston MA
International Classification:
C12P 21/06
C12P 11/00
A61K 38/00
A61K 31/67
US Classification:
435 691, 435130, 514 9, 514 95, 930260
Abstract:
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. Modified integrin I-domain polypeptides stabilized in a desired conformation are also provided, as well as screening assays and therapeutic methods utilizing the modified integrin I-domain polypeptides.

Modified Polypeptides Stabilized In A Desired Conformation And Methods For Producing Same

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US Patent:
7879577, Feb 1, 2011
Filed:
Nov 20, 2009
Appl. No.:
12/592275
Inventors:
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Chafen Lu - Newton MA, US
Assignee:
The Center for Blood Research, Inc. - Boston MA
International Classification:
C12P 21/06
C12P 11/00
A61K 38/00
A61K 31/67
US Classification:
435 691, 435130, 930260
Abstract:
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Modified Polypeptides Stabilized In A Desired Conformation And Methods For Producing Same

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US Patent:
7968284, Jun 28, 2011
Filed:
Dec 10, 2010
Appl. No.:
12/964813
Inventors:
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Chafen Lu - Newton MA, US
Assignee:
The Center for Blood Research, Inc. - Boston MA
International Classification:
C12Q 1/00
G01N 33/53
US Classification:
435 4, 435 71
Abstract:
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Modified Polypeptides Stabilized In A Desired Conformation And Methods For Producing Same

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US Patent:
8241627, Aug 14, 2012
Filed:
Jun 22, 2011
Appl. No.:
13/165873
Inventors:
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Chafen Lu - Newton MA, US
Assignee:
The Center for Blood Research, Inc. - Boston MA
International Classification:
A61K 39/395
US Classification:
4241301, 4241431, 4241441
Abstract:
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where crysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Modified Polypeptides Stabilized In A Desired Conformation And Methods For Producing Same

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US Patent:
20020123614, Sep 5, 2002
Filed:
Aug 31, 2001
Appl. No.:
09/945265
Inventors:
Timothy Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Chafen Lu - Newton MA, US
International Classification:
C07K014/435
C07H021/04
C12P021/02
C12N005/06
US Classification:
530/350000, 536/023500, 435/069100, 435/325000, 435/320100
Abstract:
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Antibodies That Bind Alphae Integrin

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US Patent:
20030232387, Dec 18, 2003
Filed:
Jun 14, 2002
Appl. No.:
10/173551
Inventors:
Chafen Lu - Newton MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
G01N033/53
A61K039/395
C07K016/28
US Classification:
435/007100, 530/388220, 424/143100
Abstract:
Antibodies and antigen-binding fragments of antibodies that bind E integrin are disclosed. Some of the antibodies and antigen-binding fragments bind an activation induced epitope on integrin E chain. In some embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods that employ the antibodies and antigen-binding fragments.

Modified Integrin Polypeptides, Modified Integrin Polypeptide Dimers, And Uses Thereof

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US Patent:
20200031900, Jan 30, 2020
Filed:
Mar 8, 2019
Appl. No.:
16/296350
Inventors:
- Boston MA, US
Xianchi DONG - Malden MA, US
Chafen LU - Newton MA, US
Assignee:
THE CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
C07K 14/705
A61K 38/17
G16C 10/00
G01N 33/68
Abstract:
Described herein are modified integrin α and/or β headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin α and/or β headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin α and/or β headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
Control profile
Chafen Lu from Chestnut Hill, MA, age ~61 Get Report