US Patent:
20040110717, Jun 10, 2004
Inventors:
Steven Carroll - Yardley PA, US
Robert LaFemina - Schwenksville PA, US
Dawn Hall - Spring City PA, US
Amy Himmelberger - Lansdale PA, US
Lawrence Kuo - Gwynedd Valley PA, US
David Olsen - Lansdale PA, US
Carrie Rutkowski - Lansdale PA, US
Joanne Tomassini - Lower Gwynedd PA, US
Malcolm MacCoss - Freehold NJ, US
Haoyun An - Carlsbad CA, US
Balkrishen Bhat - Carlsbad CA, US
Neelima Bhat - Carlsbad CA, US
Phillip Cook - Fallbrook CA, US
Anne Eldrup - Encinitas CA, US
Thazha Prakash - Carlsbad CA, US
Marija Prhavc - Carlsbad CA, US
Charles Guinosso - Chestnut Ridge NY, US
International Classification:
A61K031/7076
A61K031/7072
A61K031/519
A61K031/513
A61K031/498
A61K031/4433
US Classification:
514/045000, 514/050000, 514/249000, 514/262100, 514/269000, 514/340000
Abstract:
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.