Resumes
Resumes
Caroline Ahrens Phones & Addresses
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Annapolis, MD
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Kill Devil Hills, NC
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132 Linwood Ave, Melrose, MA 02176
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Charlestown, MA
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Owings Mills, MD
Publications
Us Patents
Hydrogel Comprising A Scaffold Macromer Crosslinked With A Peptide And A Recognition Motif
View pageUS Patent:
20180010091, Jan 11, 2018
Filed:
Jan 15, 2016
Appl. No.:
15/543866
Inventors:
- Cambridge MA, US
Barbara Imperiali - Cambridge MA, US
Christi D. Cook - Cambridge MA, US
Caroline Chopko Ahrens - Lubbock TX, US
Kasper Renggli - Cambridge MA, US
Jorge L. Valdez Macias - Cambridge MA, US
Barbara Imperiali - Cambridge MA, US
Christi D. Cook - Cambridge MA, US
Caroline Chopko Ahrens - Lubbock TX, US
Kasper Renggli - Cambridge MA, US
Jorge L. Valdez Macias - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12N 5/00
C08G 65/333
C08J 3/24
C08G 65/334
C08J 3/075
G01N 33/574
G01N 33/50
C08G 65/333
C08J 3/24
C08G 65/334
C08J 3/075
G01N 33/574
G01N 33/50
Abstract:
Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e.g. sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in the mixture comprise a recognition motif cleavable by a transpeptidase (e.g., sortase).